ID   ORML3_RAT               Reviewed;         153 AA.
AC   Q6QI25;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=ORM1-like protein 3;
DE   AltName: Full=Liver regeneration-related protein LRRGT00183;
GN   Name=Ormdl3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RA   Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. May indirectly
CC       regulate endoplasmic reticulum-mediated Ca(+2) signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS66274.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY539934; AAS66274.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001041362.1; NM_001047897.1.
DR   RefSeq; XP_006247407.1; XM_006247345.1.
DR   RefSeq; XP_006247408.1; XM_006247346.1.
DR   AlphaFoldDB; Q6QI25; -.
DR   SMR; Q6QI25; -.
DR   STRING; 10116.ENSRNOP00000046432; -.
DR   PaxDb; Q6QI25; -.
DR   PRIDE; Q6QI25; -.
DR   GeneID; 360618; -.
DR   KEGG; rno:360618; -.
DR   UCSC; RGD:1560577; rat.
DR   CTD; 94103; -.
DR   RGD; 1560577; Ormdl3.
DR   eggNOG; KOG3319; Eukaryota.
DR   InParanoid; Q6QI25; -.
DR   OrthoDB; 1405600at2759; -.
DR   PhylomeDB; Q6QI25; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-RNO-1660661; Sphingolipid de novo biosynthesis.
DR   Reactome; R-RNO-6798695; Neutrophil degranulation.
DR   PRO; PR:Q6QI25; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; ISS:UniProtKB.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:0061744; P:motor behavior; ISO:RGD.
DR   GO; GO:0042552; P:myelination; ISO:RGD.
DR   GO; GO:0002903; P:negative regulation of B cell apoptotic process; ISO:RGD.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; ISO:RGD.
DR   GO; GO:1904221; P:negative regulation of serine C-palmitoyltransferase activity; ISO:RGD.
DR   GO; GO:0010508; P:positive regulation of autophagy; ISO:RGD.
DR   GO; GO:1900182; P:positive regulation of protein localization to nucleus; ISO:RGD.
DR   GO; GO:2000303; P:regulation of ceramide biosynthetic process; ISO:RGD.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; ISO:RGD.
DR   GO; GO:0090153; P:regulation of sphingolipid biosynthetic process; ISO:RGD.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; ISO:RGD.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029883; ORML3.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF11; PTHR12665:SF11; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 3"
FT                   /id="PRO_0000215642"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17463 MW;  E37EB8D0EC58BB2D CRC64;
     MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNLGM
     YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD
     QVHFILNTVS LMSVLIPKLP QLHGVRIFGI NKY