ORN3_PLAOR
ID ORN3_PLAOR Reviewed; 41 AA.
AC P25510;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Ornatin-A3;
OS Placobdella ornata (Turtle leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Placobdella.
OX NCBI_TaxID=6415;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=1765068; DOI=10.1111/j.1432-1033.1991.tb16472.x;
RA Mazur P., Henzel W.J., Seymour J.L., Lazarus R.A.;
RT "Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet
RT aggregation inhibitors from the leech Placobdella ornata.";
RL Eur. J. Biochem. 202:1073-1082(1991).
CC -!- FUNCTION: Potent inhibitor of fibrinogen interaction with platelet
CC receptors expressed on glycoprotein IIb-IIIa complex. May prevent blood
CC from clotting during either feeding and/or storage of ingested blood.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the ornatin family. {ECO:0000305}.
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DR PIR; S19621; S19621.
DR AlphaFoldDB; P25510; -.
DR SMR; P25510; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030193; P:regulation of blood coagulation; IEA:InterPro.
DR InterPro; IPR002463; Ornatin.
DR Pfam; PF02088; Ornatin; 1.
DR PRINTS; PR01184; ORNATIN.
PE 1: Evidence at protein level;
KW Blood coagulation; Cell adhesion; Direct protein sequencing; Hemostasis;
KW Secreted.
FT CHAIN 1..41
FT /note="Ornatin-A3"
FT /id="PRO_0000215261"
FT MOTIF 33..35
FT /note="Cell attachment site"
SQ SEQUENCE 41 AA; 4386 MW; 7A3FD9D7B9C198F4 CRC64;
IPQCADIKES GQPNDKCRCN GITCTVGKCK IGRGDDNDKC T