ID   ASB12_MOUSE             Reviewed;         308 AA.
AC   Q9D738;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 12;
DE            Short=ASB-12;
GN   Name=Asb12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kile B.T., Nicola N.A.;
RT   "SOCS box proteins.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with CUL5 and RNF7. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; AK009644; BAB26410.1; -; mRNA.
DR   EMBL; AF403040; AAL57359.1; -; mRNA.
DR   CCDS; CCDS30283.1; -.
DR   RefSeq; NP_001300672.1; NM_001313743.1.
DR   RefSeq; NP_543134.1; NM_080858.3.
DR   RefSeq; XP_011245976.1; XM_011247674.2.
DR   AlphaFoldDB; Q9D738; -.
DR   SMR; Q9D738; -.
DR   BioGRID; 214021; 3.
DR   IntAct; Q9D738; 3.
DR   STRING; 10090.ENSMUSP00000033549; -.
DR   PhosphoSitePlus; Q9D738; -.
DR   PaxDb; Q9D738; -.
DR   PRIDE; Q9D738; -.
DR   ProteomicsDB; 277245; -.
DR   Antibodypedia; 27045; 58 antibodies from 14 providers.
DR   DNASU; 70392; -.
DR   Ensembl; ENSMUST00000033549; ENSMUSP00000033549; ENSMUSG00000031204.
DR   GeneID; 70392; -.
DR   KEGG; mmu:70392; -.
DR   UCSC; uc009tty.1; mouse.
DR   CTD; 142689; -.
DR   MGI; MGI:1917642; Asb12.
DR   VEuPathDB; HostDB:ENSMUSG00000031204; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000153902; -.
DR   HOGENOM; CLU_053981_1_0_1; -.
DR   InParanoid; Q9D738; -.
DR   OMA; DYNCTDR; -.
DR   OrthoDB; 1048859at2759; -.
DR   PhylomeDB; Q9D738; -.
DR   TreeFam; TF331945; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 70392; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Asb12; mouse.
DR   PRO; PR:Q9D738; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q9D738; protein.
DR   Bgee; ENSMUSG00000031204; Expressed in temporalis muscle and 60 other tissues.
DR   ExpressionAtlas; Q9D738; baseline and differential.
DR   Genevisible; Q9D738; MM.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISO:MGI.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; ISO:MGI.
DR   GO; GO:0016567; P:protein ubiquitination; ISO:MGI.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..308
FT                   /note="Ankyrin repeat and SOCS box protein 12"
FT                   /id="PRO_0000066948"
FT   REPEAT          63..92
FT                   /note="ANK 1"
FT   REPEAT          96..125
FT                   /note="ANK 2"
FT   REPEAT          129..158
FT                   /note="ANK 3"
FT   REPEAT          171..200
FT                   /note="ANK 4"
FT   REPEAT          213..243
FT                   /note="ANK 5"
FT   DOMAIN          268..308
FT                   /note="SOCS box"
SQ   SEQUENCE   308 AA;  33912 MW;  49824EE6616DB961 CRC64;
     MNLMDIAKIF SLLQPEKEEE DTGTGEKQAL NQAVYDNDSC TLDHLLHQER YKRFINSRSG
     WGIPGTPLRL AASYGHLNCV KVLLEHGADV DSLDVKAQTP LFTAVSHGHL ECVRMLLEAG
     ACPSGSIYNN CSPVLTASRD GAFAILQELL GHGAEANVKA KLPVWASNIA SCSGPLYLAA
     VYGHLDCFRL LLLYGADPDY NCTDQGLLSR VPQPRTLLEI CLHHNCEPEY IQLLIDFGAN
     IYLPSLPVDP TSQDDKGIKL LLQARATPRS LLSQTRLVIR RSLCRANQSQ ATDQLDIPPV
     LISYLKHQ