ORN4C_HUMAN
ID ORN4C_HUMAN Reviewed; 316 AA.
AC A0A096LPK9;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Olfactory receptor 4N4C {ECO:0000305};
GN Name=OR4N4C {ECO:0000312|HGNC:HGNC:55110};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC135068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LPK9; -.
DR SMR; A0A096LPK9; -.
DR STRING; 9606.ENSP00000485668; -.
DR BioMuta; ENSG00000279408; -.
DR PeptideAtlas; A0A096LPK9; -.
DR Ensembl; ENST00000623441.1; ENSP00000485668.1; ENSG00000279408.3.
DR MANE-Select; ENST00000623441.1; ENSP00000485668.1; NM_001365389.2; NP_001352318.2.
DR UCSC; uc032bup.1; human.
DR GeneCards; LINC02203; -.
DR GeneCards; OR4N4C; -.
DR HGNC; HGNC:55110; OR4N4C.
DR neXtProt; NX_A0A096LPK9; -.
DR OpenTargets; ENSG00000280709; -.
DR VEuPathDB; HostDB:ENSG00000279408; -.
DR VEuPathDB; HostDB:ENSG00000280709; -.
DR eggNOG; ENOG502SKDS; Eukaryota.
DR GeneTree; ENSGT00940000162873; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR OMA; CANTYEA; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A0A096LPK9; protein.
DR Bgee; ENSG00000279408; Expressed in left testis and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 4N4C"
FT /id="PRO_0000451614"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..143
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..243
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..316
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 316 AA; 35706 MW; 826C10BC3176C926 CRC64;
MKIANNTVVT EFILLGLTQS QDIQLLVFVL ILIFYLIILP GNFLIIFTIR SDPGLTAPLY
LFLGNLAFLD ASYSFIVAPR MLVDFLSEKK VISYRGCITQ LFFLHFLGGG EGLLLVVMAF
DRYIAICRPL HCSTVMNPRA CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD
VRQVIKLACT DMFVVELLMV FNSGLMTLLC FLGLLASYAV ILCHVRRAAS EGKNKAMSTC
TTRVIIILLM FGPAIFIYIC PFRALPADKM VSLFHTVIFP LMNPMIYTLR NQEVKTSMKR
LLSRHVVCQV DFIIRN
