ID   ORNE_PLAOR              Reviewed;          50 AA.
AC   P25514;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ornatin-E;
OS   Placobdella ornata (Turtle leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Placobdella.
OX   NCBI_TaxID=6415;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1765068; DOI=10.1111/j.1432-1033.1991.tb16472.x;
RA   Mazur P., Henzel W.J., Seymour J.L., Lazarus R.A.;
RT   "Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet
RT   aggregation inhibitors from the leech Placobdella ornata.";
RL   Eur. J. Biochem. 202:1073-1082(1991).
CC   -!- FUNCTION: Potent inhibitor of fibrinogen interaction with platelet
CC       receptors expressed on glycoprotein IIb-IIIa complex. May prevent blood
CC       from clotting during either feeding and/or storage of ingested blood.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ornatin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S19624; S19624.
DR   AlphaFoldDB; P25514; -.
DR   SMR; P25514; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030193; P:regulation of blood coagulation; IEA:InterPro.
DR   InterPro; IPR002463; Ornatin.
DR   Pfam; PF02088; Ornatin; 1.
DR   PRINTS; PR01184; ORNATIN.
PE   1: Evidence at protein level;
KW   Blood coagulation; Cell adhesion; Direct protein sequencing; Hemostasis;
KW   Secreted.
FT   CHAIN           1..50
FT                   /note="Ornatin-E"
FT                   /id="PRO_0000215265"
FT   MOTIF           42..44
FT                   /note="Cell attachment site"
SQ   SEQUENCE   50 AA;  5728 MW;  6B8408EB1E001B92 CRC64;
     IYVRPTKDEL LYCGEFRELG QPDKKCRCDG KPCTVGRCNF ARGDNDDKCI