ORNT1_MOUSE
ID ORNT1_MOUSE Reviewed; 301 AA.
AC Q9WVD5;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Mitochondrial ornithine transporter 1;
DE AltName: Full=Solute carrier family 25 member 15;
GN Name=Slc25a15; Synonyms=Ornt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10369256; DOI=10.1038/9658;
RA Camacho J.A., Obie C., Biery B., Goodman B.K., Hu A., Almashanu S.,
RA Steel G., Casey R., Lombard M., Mitchell G.A., Valle D.;
RT "Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by
RT mutations in a gene encoding a mitochondrial ornithine transporter.";
RL Nat. Genet. 22:151-158(1999).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19287344; DOI=10.1203/pdr.0b013e3181a283c1;
RA Camacho J.A., Rioseco-Camacho N.;
RT "The human and mouse SLC25A29 mitochondrial transporters rescue the
RT deficient ornithine metabolism in fibroblasts of patients with the
RT hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.";
RL Pediatr. Res. 66:35-41(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Ornithine-citrulline antiporter (PubMed:19287344). Connects
CC the cytosolic and the intramitochondrial reactions of the urea cycle by
CC exchanging cytosolic ornithine with matrix citrulline. The
CC stoichiometry is close to 1:1 (By similarity).
CC {ECO:0000250|UniProtKB:A0A0G2K309, ECO:0000269|PubMed:19287344}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:A0A0G2K309}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in the liver,
CC testis and kidney. In the brain, expressed at high levels in the
CC hypothalamus. {ECO:0000269|PubMed:19287344}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AF133914; AAD45252.1; -; mRNA.
DR CCDS; CCDS22175.1; -.
DR RefSeq; NP_851842.1; NM_181325.4.
DR RefSeq; XP_006509089.1; XM_006509026.3.
DR AlphaFoldDB; Q9WVD5; -.
DR SMR; Q9WVD5; -.
DR BioGRID; 201981; 2.
DR STRING; 10090.ENSMUSP00000033871; -.
DR iPTMnet; Q9WVD5; -.
DR PhosphoSitePlus; Q9WVD5; -.
DR SwissPalm; Q9WVD5; -.
DR EPD; Q9WVD5; -.
DR jPOST; Q9WVD5; -.
DR MaxQB; Q9WVD5; -.
DR PaxDb; Q9WVD5; -.
DR PRIDE; Q9WVD5; -.
DR ProteomicsDB; 287745; -.
DR Antibodypedia; 42171; 81 antibodies from 20 providers.
DR DNASU; 18408; -.
DR Ensembl; ENSMUST00000033871; ENSMUSP00000033871; ENSMUSG00000031482.
DR GeneID; 18408; -.
DR KEGG; mmu:18408; -.
DR UCSC; uc009lcz.2; mouse.
DR CTD; 10166; -.
DR MGI; MGI:1342274; Slc25a15.
DR VEuPathDB; HostDB:ENSMUSG00000031482; -.
DR eggNOG; KOG0763; Eukaryota.
DR GeneTree; ENSGT00730000110966; -.
DR HOGENOM; CLU_015166_16_3_1; -.
DR InParanoid; Q9WVD5; -.
DR OMA; PIDCFRQ; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q9WVD5; -.
DR TreeFam; TF314880; -.
DR Reactome; R-MMU-70635; Urea cycle.
DR BioGRID-ORCS; 18408; 5 hits in 78 CRISPR screens.
DR ChiTaRS; Slc25a15; mouse.
DR PRO; PR:Q9WVD5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9WVD5; protein.
DR Bgee; ENSMUSG00000031482; Expressed in epithelium of small intestine and 243 other tissues.
DR ExpressionAtlas; Q9WVD5; baseline and differential.
DR Genevisible; Q9WVD5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015297; F:antiporter activity; ISS:UniProtKB.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; ISO:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903826; P:L-arginine transmembrane transport; ISS:UniProtKB.
DR GO; GO:1903401; P:L-lysine transmembrane transport; ISS:UniProtKB.
DR GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..301
FT /note="Mitochondrial ornithine transporter 1"
FT /id="PRO_0000090651"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 7..91
FT /note="Solcar 1"
FT REPEAT 104..197
FT /note="Solcar 2"
FT REPEAT 207..293
FT /note="Solcar 3"
SQ SEQUENCE 301 AA; 32823 MW; 36F232F781785D2B CRC64;
MKSNPAIQAA IDLTAGAAGG TACVLTGQPF DTMKVKMQTF PDLYRGLTDC CLKTYSQVGF
RGFYKGTSPA LIANIAENSV LFMCYGFCQQ VVRKVVGLDQ QAKLSDLQNA AAGSFASAFA
ALVLCPTELV KCRLQTMYEM ETSGKIAASQ NTVWSVVKEI FRKDGPLGFY HGLSSTLLRE
VPGYFFFFGG YELSRSFFAS GRSKDELGPV PLMLSGGFGG ICLWLAVYPV DCIKSRIQVL
SMTGKQTGLV RTFLSIVKNE GITALYSGLK PTMIRAFPAN GALFLAYEYS RKLMMNQLEA
W
