ORN_BURM9
ID ORN_BURM9 Reviewed; 201 AA.
AC A2S4M9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Oligoribonuclease {ECO:0000255|HAMAP-Rule:MF_00045};
DE EC=3.1.15.- {ECO:0000255|HAMAP-Rule:MF_00045};
GN Name=orn {ECO:0000255|HAMAP-Rule:MF_00045};
GN OrderedLocusNames=BMA10229_A0908;
OS Burkholderia mallei (strain NCTC 10229).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=412022;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 10229;
RX PubMed=20333227; DOI=10.1093/gbe/evq003;
RA Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA Nierman W.C.;
RT "Continuing evolution of Burkholderia mallei through genome reduction and
RT large-scale rearrangements.";
RL Genome Biol. Evol. 2:102-116(2010).
CC -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC oligoribonucleotides. {ECO:0000255|HAMAP-Rule:MF_00045}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00045}.
CC -!- SIMILARITY: Belongs to the oligoribonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00045}.
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DR EMBL; CP000546; ABN02476.1; -; Genomic_DNA.
DR RefSeq; WP_004189767.1; NC_008836.1.
DR AlphaFoldDB; A2S4M9; -.
DR SMR; A2S4M9; -.
DR EnsemblBacteria; ABN02476; ABN02476; BMA10229_A0908.
DR GeneID; 56596477; -.
DR KEGG; bml:BMA10229_A0908; -.
DR HOGENOM; CLU_064761_2_0_4; -.
DR OMA; AFFHYRN; -.
DR Proteomes; UP000002283; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06135; Orn; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR HAMAP; MF_00045; Oligoribonuclease; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR022894; Oligoribonuclease.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11046; PTHR11046; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..201
FT /note="Oligoribonuclease"
FT /id="PRO_1000004236"
FT DOMAIN 20..183
FT /note="Exonuclease"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT ACT_SITE 141
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
SQ SEQUENCE 201 AA; 22580 MW; 72C6573F6E7824DD CRC64;
MTDISAVAGQ PALVRNELNL VWLDMEMTGL DPDTDRIIEI AVVVTNSTLD IAVEGPVLAI
HQSDETLAKM DDWNKNTHGR SGLIDRVRAS SVTEADAAAQ IAAFLAEHVP PGKSPMCGNS
ICQDRRFMAR WMPELERFFH YRNLDVSTLK ELCRRWQPAI YKGFQKRAMH TALADIHESI
DELKYYRERF LIPAAPAGET A