ASB14_MOUSE
ID ASB14_MOUSE Reviewed; 587 AA.
AC Q8C6Y6; B7ZN45; Q8VHS7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Ankyrin repeat and SOCS box protein 14;
GN Name=Asb14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-587 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C6Y6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C6Y6-2; Sequence=VSP_036929, VSP_036930;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35189.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF403042; AAL57361.1; -; mRNA.
DR EMBL; AK052884; BAC35189.1; ALT_INIT; mRNA.
DR EMBL; AC133179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC145002; AAI45003.1; -; mRNA.
DR CCDS; CCDS49431.2; -. [Q8C6Y6-1]
DR RefSeq; NP_001164219.1; NM_001170748.1.
DR RefSeq; NP_543132.3; NM_080856.4.
DR AlphaFoldDB; Q8C6Y6; -.
DR SMR; Q8C6Y6; -.
DR STRING; 10090.ENSMUSP00000087810; -.
DR iPTMnet; Q8C6Y6; -.
DR PhosphoSitePlus; Q8C6Y6; -.
DR PaxDb; Q8C6Y6; -.
DR PRIDE; Q8C6Y6; -.
DR ProteomicsDB; 283181; -. [Q8C6Y6-1]
DR ProteomicsDB; 283182; -. [Q8C6Y6-2]
DR DNASU; 142687; -.
DR GeneID; 142687; -.
DR KEGG; mmu:142687; -.
DR CTD; 142686; -.
DR MGI; MGI:2655107; Asb14.
DR eggNOG; KOG0504; Eukaryota.
DR InParanoid; Q8C6Y6; -.
DR OrthoDB; 311534at2759; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 142687; 5 hits in 73 CRISPR screens.
DR PRO; PR:Q8C6Y6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8C6Y6; protein.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..587
FT /note="Ankyrin repeat and SOCS box protein 14"
FT /id="PRO_0000370366"
FT REPEAT 81..110
FT /note="ANK 1"
FT REPEAT 116..145
FT /note="ANK 2"
FT REPEAT 149..178
FT /note="ANK 3"
FT REPEAT 182..211
FT /note="ANK 4"
FT REPEAT 215..244
FT /note="ANK 5"
FT REPEAT 248..277
FT /note="ANK 6"
FT REPEAT 281..310
FT /note="ANK 7"
FT REPEAT 313..342
FT /note="ANK 8"
FT REPEAT 355..384
FT /note="ANK 9"
FT REPEAT 385..414
FT /note="ANK 10"
FT REPEAT 416..449
FT /note="ANK 11"
FT DOMAIN 521..576
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VAR_SEQ 1..164
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036929"
FT VAR_SEQ 239
FT /note="G -> GKAYLMVDYRG (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036930"
FT CONFLICT 310
FT /note="I -> V (in Ref. 1; AAL57361)"
FT /evidence="ECO:0000305"
FT CONFLICT 529..587
FT /note="ANPRSLQHLCRLKIRKCMGRLRLRCPVFMSFLPLPNLLKAYVLYKEYDLFGQ
FT ERSTGTW -> SEYRSHRKFLPKH (in Ref. 2; BAC35189)"
FT /evidence="ECO:0000305"
FT CONFLICT 529
FT /note="A -> T (in Ref. 1; AAL57361 and 4; AAI45003)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 587 AA; 64883 MW; 3A9395532FA6712C CRC64;
MDPSGSDEDA DADFDTQVII QQSLLDVYKP GIAQHTPEAA RLHSFPSDDY KKIAEAIETG
KEDALAGFAK YHPAFDEANG NGWLPLHKAA VQLNKNILEI TMNASEPSTW ERTTHNGETA
LFLAVSSSLL ENAHFLLLKG CNPNAKTSEG NSPLLTAVLK DAYDMATLLI SHGADVNLRC
ANERTALHEA AKLGRLDMVK LMLASGAYPD ARSSYGFTPL ALAAQGGHTG IMQLLLQKGA
DVHSQASDSS SVLLEAVRGG NPEAVSLLLE YGADANIPKS SGHLPIHVAA DKGHFLALKV
LVPVTDIAAI KKSGISPVHC AAAGAHPHCL ELLIQAGFDV NFMLDQRIRK HYDDQRKSAL
YFAVSNGDLP SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LISLLLRHGA NVNYFCRVNP
LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGERVH RFCTFEGWTS TVIKDTMFCE
VITLSWLQHL SGKVVRVMLD YVDQVQICSK LKAVLEKQRL WPEIHFILAN PRSLQHLCRL
KIRKCMGRLR LRCPVFMSFL PLPNLLKAYV LYKEYDLFGQ ERSTGTW
