ASB14_RAT
ID ASB14_RAT Reviewed; 596 AA.
AC P0C927;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Ankyrin repeat and SOCS box protein 14;
GN Name=Asb14;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AABR03100346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0C927; -.
DR SMR; P0C927; -.
DR STRING; 10116.ENSRNOP00000017995; -.
DR PaxDb; P0C927; -.
DR UCSC; RGD:1596812; rat.
DR RGD; 1596812; Asb14.
DR eggNOG; KOG0504; Eukaryota.
DR InParanoid; P0C927; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:P0C927; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..596
FT /note="Ankyrin repeat and SOCS box protein 14"
FT /id="PRO_0000370367"
FT REPEAT 90..119
FT /note="ANK 1"
FT REPEAT 125..154
FT /note="ANK 2"
FT REPEAT 158..187
FT /note="ANK 3"
FT REPEAT 191..220
FT /note="ANK 4"
FT REPEAT 224..254
FT /note="ANK 5"
FT REPEAT 258..287
FT /note="ANK 6"
FT REPEAT 291..320
FT /note="ANK 7"
FT REPEAT 323..352
FT /note="ANK 8"
FT REPEAT 365..394
FT /note="ANK 9"
FT REPEAT 395..424
FT /note="ANK 10"
FT REPEAT 426..459
FT /note="ANK 11"
FT DOMAIN 531..586
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ SEQUENCE 596 AA; 66181 MW; 66502EA46A8EB329 CRC64;
MDQQSSDEDA DTDFDTQIII QQSLLDAYKP ELTGRTPEDE RSQSFSSEDY KKIVEAIETV
KYSSYPRPSK EDALASFAKY HPAFDEANGS GWLPLHKAAV QLNKNILEIT LNASKPSAWE
QTTRNGETPL FLAVSSSLLE NAHFLLLNGC DPNAKNFEGN SPLLTAVLKD SYDMATLLIN
HGANVNLRCA NERTALHEAA KLGRQDMVKL MLSSGANPDA RSSYGFTPLA LAAQGGHTET
MQLLLQKGRA DVHSQASDSS SVLLEAVRGG DPDSVSLLLE YGADANIPKS SGHLPIHVAA
DKGHFLALKV LVPVTDIAAI KRSGISPLHC AAAGAHPQCL DLLIRAGFDV NFMLDQRVRK
HYDDQRKSAL YFAVSNGDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LINLLLRHGA
NVNYFCRVNP LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGERVH RCCTFEGWTS
TVIKDTMFCE VITLSWLQHL SGKVVRVMLD YVDQVQICSK LKAVLEKQKL WPEIHVILTN
PRSLQHLCRL KIRKCMGRLR LRCPVFMSFL PLPNLLKAYV LYKEYDLYGQ GSSTGT
