ID   ORN_DICDI               Reviewed;         190 AA.
AC   Q556Y2; Q86AJ1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable oligoribonuclease;
DE            EC=3.1.15.-;
DE   AltName: Full=RNA exonuclease 2 homolog;
GN   Name=rexo2-1; ORFNames=DDB_G0273355;
GN   and
GN   Name=rexo2-2; ORFNames=DDB_G0273741;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC       oligoribonucleotides. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the oligoribonuclease family. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70561.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70895.1; -; Genomic_DNA.
DR   RefSeq; XP_644487.1; XM_639395.1.
DR   RefSeq; XP_644763.1; XM_639671.1.
DR   AlphaFoldDB; Q556Y2; -.
DR   SMR; Q556Y2; -.
DR   STRING; 44689.DDB0305003; -.
DR   PaxDb; Q556Y2; -.
DR   EnsemblProtists; EAL70561; EAL70561; DDB_G0273741.
DR   EnsemblProtists; EAL70895; EAL70895; DDB_G0273355.
DR   GeneID; 8618865; -.
DR   GeneID; 8619111; -.
DR   KEGG; ddi:DDB_G0273355; -.
DR   KEGG; ddi:DDB_G0273741; -.
DR   dictyBase; DDB_G0273355; rexo2-1.
DR   dictyBase; DDB_G0273741; rexo2-2.
DR   eggNOG; KOG3242; Eukaryota.
DR   HOGENOM; CLU_064761_2_0_1; -.
DR   InParanoid; Q556Y2; -.
DR   OMA; AFFHYRN; -.
DR   PhylomeDB; Q556Y2; -.
DR   PRO; PR:Q556Y2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; ISS:dictyBase.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016070; P:RNA metabolic process; IC:dictyBase.
DR   CDD; cd06135; Orn; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR022894; Oligoribonuclease.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR11046; PTHR11046; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Probable oligoribonuclease"
FT                   /id="PRO_0000328288"
FT   DOMAIN          19..181
FT                   /note="Exonuclease"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  22110 MW;  C1A993ED99613249 CRC64;
     MSTTPTYNHP VINERSKRMV WVDLEMTGLD ISKDVILEMA IVITDAELNV IEKGPNLVIH
     RSDEVLKNMN DWCIEHHGKS GLTEDVRNSK ISLEEAEKIM LEFVRKHTDK GICPLAGNTV
     HEDRRFLLKE MPTFAEHLHY RIIDVSTIKE LSRRWYPYIP SPKKVCGHRA LQDIEESIEE
     LKSYRVTVFK