ASB15_BOVIN
ID ASB15_BOVIN Reviewed; 588 AA.
AC Q8HXA6; Q08DG3;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Ankyrin repeat and SOCS box protein 15;
DE Short=ASB-15;
GN Name=ASB15;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=12755830; DOI=10.1046/j.1365-2052.2003.01004.x;
RA McDaneld T.G., Moody D.E.;
RT "Characterization of a bovine gene encoding an ankyrin repeat and SOCS box
RT protein (ASB15).";
RL Anim. Genet. 34:235-236(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AF541277; AAN23151.1; -; Genomic_DNA.
DR EMBL; AF541269; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541270; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541271; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541272; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541273; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541274; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541275; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF541276; AAN23151.1; JOINED; Genomic_DNA.
DR EMBL; AF527382; AAN38732.1; -; mRNA.
DR EMBL; BC123763; AAI23764.1; -; mRNA.
DR RefSeq; NP_777112.1; NM_174687.2.
DR AlphaFoldDB; Q8HXA6; -.
DR SMR; Q8HXA6; -.
DR STRING; 9913.ENSBTAP00000002787; -.
DR PaxDb; Q8HXA6; -.
DR PRIDE; Q8HXA6; -.
DR Ensembl; ENSBTAT00000002787; ENSBTAP00000002787; ENSBTAG00000002151.
DR GeneID; 282591; -.
DR KEGG; bta:282591; -.
DR CTD; 142685; -.
DR VEuPathDB; HostDB:ENSBTAG00000002151; -.
DR VGNC; VGNC:26192; ASB15.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000157073; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; Q8HXA6; -.
DR OMA; FMRVNDT; -.
DR OrthoDB; 311534at2759; -.
DR TreeFam; TF315127; -.
DR Reactome; R-BTA-8951664; Neddylation.
DR Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000002151; Expressed in choroid plexus and 38 other tissues.
DR GO; GO:0030315; C:T-tubule; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0036371; P:protein localization to T-tubule; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0055117; P:regulation of cardiac muscle contraction; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..588
FT /note="Ankyrin repeat and SOCS box protein 15"
FT /id="PRO_0000066953"
FT REPEAT 75..104
FT /note="ANK 1"
FT REPEAT 110..139
FT /note="ANK 2"
FT REPEAT 143..172
FT /note="ANK 3"
FT REPEAT 176..205
FT /note="ANK 4"
FT REPEAT 209..238
FT /note="ANK 5"
FT REPEAT 242..271
FT /note="ANK 6"
FT REPEAT 275..304
FT /note="ANK 7"
FT REPEAT 307..336
FT /note="ANK 8"
FT REPEAT 349..378
FT /note="ANK 9"
FT REPEAT 379..408
FT /note="ANK 10"
FT REPEAT 416..444
FT /note="ANK 11"
FT DOMAIN 524..579
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT CONFLICT 61
FT /note="E -> G (in Ref. 1; AAN23151/AAN38732)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 588 AA; 65851 MW; 8981C885B4F4C6B6 CRC64;
MDANDDPDED HLTSYDVQLS IQESIEAGKT VFYPERFVPL SDQNRKLVEA IQQGHILELQ
EYVKYKYALD EADEKGWFPL HEAVVQPIQQ ILEVVLDASY KTLWEFKTSD GETPLTLAVK
AGLVENVRTL LEKGVWPNTK NDKGETPLLL AIKRGSYDMV SALLKHNTSL DQPCVKRWSA
MHEAAKQGHK DIIALLLNNG GNVHLKDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA
DDGASVLFEA AGGGNPDCIS LLLEYGGSGN IPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
KHAIQKSGLT PIHSAADGQN AQCLELLIEN GFDVNSLLAD HISESYDDER KTALYFAVCN
NDILCTEILL AAGADPNLDP LNCLLVAVRA NNHEIVRLLL AHGANVNCYF MHVNDTRFPS
AIQYALNDEV MLRLLLNNGY QVEMCFECMH GDIFGNSFVW SEIEEEVLPG WTSCVIKDNP
FCEFITVPWM KHLVGSVIRV LIDYMDYIPL CAKLKSALEV QREWPEIRQI LENPCSLKHL
CRLKIRRLMG LQRLCQPTLM EKLSLPPTIQ RYILFKEYDL YGQELNLP
