ASB15_HUMAN
ID ASB15_HUMAN Reviewed; 588 AA.
AC Q8WXK1; Q3ZCP3; Q3ZCP5; Q68D37;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Ankyrin repeat and SOCS box protein 15;
DE Short=ASB-15;
GN Name=ASB15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-57 AND ALA-357.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-241, AND VARIANT LEU-57.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-588, AND VARIANT ALA-357.
RC TISSUE=Liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 155-588.
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q8WXK1; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-12809012, EBI-10961312;
CC Q8WXK1; P55040: GEM; NbExp=3; IntAct=EBI-12809012, EBI-744104;
CC Q8WXK1; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12809012, EBI-347538;
CC Q8WXK1; P56524-2: HDAC4; NbExp=3; IntAct=EBI-12809012, EBI-11953488;
CC Q8WXK1; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-12809012, EBI-2556193;
CC Q8WXK1; O95678: KRT75; NbExp=3; IntAct=EBI-12809012, EBI-2949715;
CC Q8WXK1; P25800: LMO1; NbExp=3; IntAct=EBI-12809012, EBI-8639312;
CC Q8WXK1; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-12809012, EBI-14086479;
CC Q8WXK1; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-12809012, EBI-1567797;
CC Q8WXK1; P0CG20: PRR35; NbExp=3; IntAct=EBI-12809012, EBI-11986293;
CC Q8WXK1; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-12809012, EBI-739895;
CC Q8WXK1; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-12809012, EBI-8656416;
CC Q8WXK1; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12809012, EBI-6427977;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AK125360; BAC86146.1; -; mRNA.
DR EMBL; AC006333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100874; AAI00875.1; -; mRNA.
DR EMBL; BC100875; AAI00876.1; -; mRNA.
DR EMBL; BC100876; AAI00877.1; -; mRNA.
DR EMBL; BC100877; AAI00878.1; -; mRNA.
DR EMBL; CR749595; CAH18393.1; -; mRNA.
DR EMBL; AF403033; AAL57352.1; -; mRNA.
DR CCDS; CCDS34742.1; -.
DR RefSeq; NP_001277187.1; NM_001290258.1.
DR RefSeq; NP_563616.3; NM_080928.4.
DR RefSeq; XP_005250203.1; XM_005250146.4.
DR RefSeq; XP_011514119.1; XM_011515817.2.
DR RefSeq; XP_011514120.1; XM_011515818.2.
DR RefSeq; XP_011514121.1; XM_011515819.2.
DR RefSeq; XP_011514122.1; XM_011515820.2.
DR RefSeq; XP_016867245.1; XM_017011756.1.
DR RefSeq; XP_016867246.1; XM_017011757.1.
DR AlphaFoldDB; Q8WXK1; -.
DR SMR; Q8WXK1; -.
DR BioGRID; 126774; 32.
DR IntAct; Q8WXK1; 14.
DR STRING; 9606.ENSP00000397655; -.
DR iPTMnet; Q8WXK1; -.
DR PhosphoSitePlus; Q8WXK1; -.
DR BioMuta; ASB15; -.
DR DMDM; 296439431; -.
DR PaxDb; Q8WXK1; -.
DR PeptideAtlas; Q8WXK1; -.
DR PRIDE; Q8WXK1; -.
DR ProteomicsDB; 75072; -.
DR Antibodypedia; 31758; 7 antibodies from 6 providers.
DR DNASU; 142685; -.
DR Ensembl; ENST00000275699.4; ENSP00000275699.3; ENSG00000146809.14.
DR Ensembl; ENST00000434204.5; ENSP00000390963.1; ENSG00000146809.14.
DR Ensembl; ENST00000451215.6; ENSP00000416433.1; ENSG00000146809.14.
DR Ensembl; ENST00000451558.5; ENSP00000397655.1; ENSG00000146809.14.
DR GeneID; 142685; -.
DR KEGG; hsa:142685; -.
DR MANE-Select; ENST00000451215.6; ENSP00000416433.1; NM_001290258.2; NP_001277187.1.
DR UCSC; uc003vku.1; human.
DR CTD; 142685; -.
DR DisGeNET; 142685; -.
DR GeneCards; ASB15; -.
DR HGNC; HGNC:19767; ASB15.
DR HPA; ENSG00000146809; Tissue enhanced (heart muscle, skeletal muscle, tongue).
DR MIM; 619757; gene.
DR neXtProt; NX_Q8WXK1; -.
DR OpenTargets; ENSG00000146809; -.
DR PharmGKB; PA134977130; -.
DR VEuPathDB; HostDB:ENSG00000146809; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000157073; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; Q8WXK1; -.
DR OMA; FMRVNDT; -.
DR OrthoDB; 311534at2759; -.
DR PhylomeDB; Q8WXK1; -.
DR TreeFam; TF315127; -.
DR PathwayCommons; Q8WXK1; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8WXK1; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 142685; 12 hits in 1108 CRISPR screens.
DR ChiTaRS; ASB15; human.
DR GenomeRNAi; 142685; -.
DR Pharos; Q8WXK1; Tdark.
DR PRO; PR:Q8WXK1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8WXK1; protein.
DR Bgee; ENSG00000146809; Expressed in hindlimb stylopod muscle and 56 other tissues.
DR ExpressionAtlas; Q8WXK1; baseline and differential.
DR Genevisible; Q8WXK1; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..588
FT /note="Ankyrin repeat and SOCS box protein 15"
FT /id="PRO_0000066954"
FT REPEAT 110..142
FT /note="ANK 1"
FT REPEAT 143..174
FT /note="ANK 2"
FT REPEAT 176..208
FT /note="ANK 3"
FT REPEAT 209..241
FT /note="ANK 4"
FT REPEAT 242..274
FT /note="ANK 5"
FT REPEAT 307..339
FT /note="ANK 6"
FT REPEAT 349..380
FT /note="ANK 7"
FT REPEAT 381..413
FT /note="ANK 8"
FT REPEAT 416..444
FT /note="ANK 9"
FT DOMAIN 524..579
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VARIANT 57
FT /note="P -> L (in dbSNP:rs6962756)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_060466"
FT VARIANT 357
FT /note="G -> A (in dbSNP:rs4731112)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_060467"
FT CONFLICT 346
FT /note="Y -> C (in Ref. 1; BAC86146)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 588 AA; 65799 MW; B3FD2435776B343D CRC64;
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ
EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK
AGLVENVRTL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV STLIKHNTSL DQPCVKRWSA
MHEAAKQGRK DIVALLLKHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA
DDGASVLFEA AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER KTALYFGVSN
NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL SHGANVNCYF MHVNDTRFPS
VIQYALNDEV MLRLLLNNGY QVEMCFDCMH GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP
FCEFITVPWM KHLVGRVTRV LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL
CRLKIRRLMG LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT
