ID   ORN_HAEIN               Reviewed;         182 AA.
AC   P45340;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Oligoribonuclease;
DE            EC=3.1.15.-;
GN   Name=orn; OrderedLocusNames=HI_1715;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC       oligoribonucleotides. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the oligoribonuclease family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23360.1; -; Genomic_DNA.
DR   PIR; C64176; C64176.
DR   RefSeq; NP_439857.1; NC_000907.1.
DR   RefSeq; WP_005694199.1; NC_000907.1.
DR   PDB; 1J9A; X-ray; 2.50 A; A=1-182.
DR   PDBsum; 1J9A; -.
DR   AlphaFoldDB; P45340; -.
DR   SMR; P45340; -.
DR   STRING; 71421.HI_1715; -.
DR   EnsemblBacteria; AAC23360; AAC23360; HI_1715.
DR   KEGG; hin:HI_1715; -.
DR   PATRIC; fig|71421.8.peg.1794; -.
DR   eggNOG; COG1949; Bacteria.
DR   HOGENOM; CLU_064761_2_0_6; -.
DR   OMA; AFFHYRN; -.
DR   PhylomeDB; P45340; -.
DR   BioCyc; HINF71421:G1GJ1-1730-MON; -.
DR   EvolutionaryTrace; P45340; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd06135; Orn; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00045; Oligoribonuclease; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR022894; Oligoribonuclease.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR11046; PTHR11046; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Exonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..182
FT                   /note="Oligoribonuclease"
FT                   /id="PRO_0000111039"
FT   DOMAIN          8..171
FT                   /note="Exonuclease"
FT   ACT_SITE        129
FT                   /evidence="ECO:0000255"
FT   STRAND          8..18
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   TURN            20..22
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   STRAND          25..33
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   STRAND          39..42
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           52..56
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           60..69
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           71..75
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           82..93
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   TURN            94..96
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   TURN            99..101
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   STRAND          104..108
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           109..119
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           121..125
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   STRAND          131..133
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           134..144
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           146..151
FT                   /evidence="ECO:0007829|PDB:1J9A"
FT   HELIX           160..177
FT                   /evidence="ECO:0007829|PDB:1J9A"
SQ   SEQUENCE   182 AA;  21199 MW;  B78FF5D619915D29 CRC64;
     MSFDKQNLIW IDLEMTGLDP EKERIIEIAT IVTDKNLNIL AEGPVLAVHQ SDELLNKMND
     WCQKTHSENG LIERIKASKL TERAAELQTL DFLKKWVPKG ASPICGNSIA QDKRFLVKYM
     PDLADYFHYR HLDVSTLKEL AARWKPEILE GFKKENTHLA LDDIRESIKE LAYYREHFMK
     LD