ASB15_MOUSE
ID ASB15_MOUSE Reviewed; 583 AA.
AC Q8VHS6; Q8CDP8;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Ankyrin repeat and SOCS box protein 15;
DE Short=ASB-15;
GN Name=Asb15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q8VHS6; Q80W03: Tox3; NbExp=2; IntAct=EBI-26675998, EBI-26675915;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AF403043; AAL57362.1; -; mRNA.
DR EMBL; AK029759; BAC26602.1; -; mRNA.
DR EMBL; AC153635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466533; EDL13821.1; -; Genomic_DNA.
DR EMBL; BC050794; AAH50794.1; -; mRNA.
DR CCDS; CCDS19943.1; -.
DR RefSeq; NP_543123.2; NM_080847.3.
DR RefSeq; XP_011239391.1; XM_011241089.1.
DR AlphaFoldDB; Q8VHS6; -.
DR SMR; Q8VHS6; -.
DR BioGRID; 219698; 4.
DR IntAct; Q8VHS6; 4.
DR STRING; 10090.ENSMUSP00000031696; -.
DR iPTMnet; Q8VHS6; -.
DR PhosphoSitePlus; Q8VHS6; -.
DR PaxDb; Q8VHS6; -.
DR PRIDE; Q8VHS6; -.
DR ProteomicsDB; 265115; -.
DR Antibodypedia; 31758; 7 antibodies from 6 providers.
DR DNASU; 78910; -.
DR Ensembl; ENSMUST00000031696; ENSMUSP00000031696; ENSMUSG00000029685.
DR Ensembl; ENSMUST00000117688; ENSMUSP00000112965; ENSMUSG00000029685.
DR GeneID; 78910; -.
DR KEGG; mmu:78910; -.
DR UCSC; uc009bbt.2; mouse.
DR CTD; 142685; -.
DR MGI; MGI:1926160; Asb15.
DR VEuPathDB; HostDB:ENSMUSG00000029685; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000157073; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; Q8VHS6; -.
DR OMA; FMRVNDT; -.
DR OrthoDB; 311534at2759; -.
DR PhylomeDB; Q8VHS6; -.
DR TreeFam; TF315127; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 78910; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q8VHS6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8VHS6; protein.
DR Bgee; ENSMUSG00000029685; Expressed in myocardium of ventricle and 59 other tissues.
DR Genevisible; Q8VHS6; MM.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..583
FT /note="Ankyrin repeat and SOCS box protein 15"
FT /id="PRO_0000066955"
FT REPEAT 75..104
FT /note="ANK 1"
FT REPEAT 110..139
FT /note="ANK 2"
FT REPEAT 143..172
FT /note="ANK 3"
FT REPEAT 176..205
FT /note="ANK 4"
FT REPEAT 209..238
FT /note="ANK 5"
FT REPEAT 242..271
FT /note="ANK 6"
FT REPEAT 275..304
FT /note="ANK 7"
FT REPEAT 307..336
FT /note="ANK 8"
FT REPEAT 349..378
FT /note="ANK 9"
FT REPEAT 379..408
FT /note="ANK 10"
FT REPEAT 416..444
FT /note="ANK 11"
FT DOMAIN 524..579
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT CONFLICT 335
FT /note="N -> K (in Ref. 1; AAL57362)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 583 AA; 65512 MW; D6115A548EC8CB3B CRC64;
MDINDDSNDD HLASYDIQLC IQESIEASQA IFHPKRLVQL SDQNRKLVEA IRQGRIFELQ
EYVQYKYALE EADEKGWFPL HEAVVQPIQQ ILETVLDASY KTLWEFKTCD GETPLTLAVK
AGLVENVKTL LDKGVWPNTK NDKGETPLLI AIKRGSYDMV SALIKYNTSL DQPCVKRWSA
MHEAAKQGRK DIITLLLNHR GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVFALA
DDGASVLFEA AGGGNPDCIS LLLKYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
KHAIQKSGLT PIHSAAEGQN AQCLELLIEN GFDVNALLAD HISQSYDDER KTALYFAVSN
NDIHCTEVLL AAGADPNLDP LNCLLVAVRA NRHEIVRLLL SYGANVNCYF MHVNDTRFPS
AIQYALNDEI MLRLLLNNGY QVELCFDCMH GNIFGNSFVW SETEEEGLPG WTSCIIKDNP
FCEFITVPWM KHLVGGIVRI LIDYMDYVPL CAKLKSVLEV QREWPEIRQI IENPCSLKHL
CRLKIRRVMG LQRLCQPASI QMLPLPAAMR RYLLFKEFDL YGQ
