ID   ASB16_MOUSE             Reviewed;         453 AA.
AC   Q8VHS5; Q8BYT0;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 16;
DE            Short=ASB-16;
GN   Name=Asb16;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kile B.T., Nicola N.A.;
RT   "SOCS box proteins.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-453.
RC   STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; AF403044; AAL57363.1; -; mRNA.
DR   EMBL; AK038411; BAC29990.1; -; mRNA.
DR   CCDS; CCDS25493.1; -.
DR   RefSeq; NP_683755.1; NM_148953.2.
DR   AlphaFoldDB; Q8VHS5; -.
DR   SMR; Q8VHS5; -.
DR   STRING; 10090.ENSMUSP00000038450; -.
DR   PhosphoSitePlus; Q8VHS5; -.
DR   PaxDb; Q8VHS5; -.
DR   PRIDE; Q8VHS5; -.
DR   ProteomicsDB; 277246; -.
DR   Antibodypedia; 77181; 6 antibodies from 4 providers.
DR   DNASU; 217217; -.
DR   Ensembl; ENSMUST00000036467; ENSMUSP00000038450; ENSMUSG00000034768.
DR   GeneID; 217217; -.
DR   KEGG; mmu:217217; -.
DR   UCSC; uc007lra.1; mouse.
DR   CTD; 92591; -.
DR   MGI; MGI:2654437; Asb16.
DR   VEuPathDB; HostDB:ENSMUSG00000034768; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000160773; -.
DR   HOGENOM; CLU_035721_2_0_1; -.
DR   InParanoid; Q8VHS5; -.
DR   OMA; GSCRRHQ; -.
DR   OrthoDB; 540084at2759; -.
DR   PhylomeDB; Q8VHS5; -.
DR   TreeFam; TF333494; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 217217; 4 hits in 73 CRISPR screens.
DR   ChiTaRS; Asb16; mouse.
DR   PRO; PR:Q8VHS5; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8VHS5; protein.
DR   Bgee; ENSMUSG00000034768; Expressed in hindlimb stylopod muscle and 24 other tissues.
DR   Genevisible; Q8VHS5; MM.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..453
FT                   /note="Ankyrin repeat and SOCS box protein 16"
FT                   /id="PRO_0000066957"
FT   REPEAT          56..85
FT                   /note="ANK 1"
FT   REPEAT          110..139
FT                   /note="ANK 2"
FT   REPEAT          142..171
FT                   /note="ANK 3"
FT   REPEAT          175..204
FT                   /note="ANK 4"
FT   REPEAT          209..238
FT                   /note="ANK 5"
FT   REPEAT          242..279
FT                   /note="ANK 6"
FT   REPEAT          283..312
FT                   /note="ANK 7"
FT   DOMAIN          397..453
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   453 AA;  49097 MW;  6B8F4FB0165981F2 CRC64;
     MAGESFPFTS STLRALRLQR EWLDWEDRRR AAAQQCRRHR DLPCPQAQLL RPRRSCRDPA
     VHNALFSGDL QQLQILFQDE DAANMIVETV SNQLAWSAEQ GFWVLTPKTK QTAPLTIAVA
     RGYTDCARHL ILQGAELDAR IGGRAALHEA CAQAHPDCVR LLLTFGAKAN VSSEEGMTPL
     HLCTSPESLQ CAKLLLEAGA SVNVASQESE VTPLHVAAAR GLEQHVALYL QNGADVALRT
     SQGETALNAA CAGAEGPGSS RQHEAAARQL LEAGADPQAA GRKRHTPLHN ACANGCGGLA
     ELLLRHGASP GVTNGAGHTP MDCALQAVQD APNWEPEVLF AALLDYGAQP VHPEMLKHCA
     NFPRALEVLL NAYPCVPSCD PWVEAVLPEL WQEHEAFYSS ALSMENQPRQ LQHLARLAVR
     AQLGSHCRQA AAQLPLPPLL RDYLLLGVEG RIQ