ID   ASB17_BOVIN             Reviewed;         295 AA.
AC   Q32KY8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE            Short=ASB-17;
GN   Name=ASB17;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; BC109851; AAI09852.1; -; mRNA.
DR   RefSeq; NP_001069898.1; NM_001076430.2.
DR   AlphaFoldDB; Q32KY8; -.
DR   STRING; 9913.ENSBTAP00000007708; -.
DR   PaxDb; Q32KY8; -.
DR   Ensembl; ENSBTAT00000007708; ENSBTAP00000007708; ENSBTAG00000005864.
DR   GeneID; 616654; -.
DR   KEGG; bta:616654; -.
DR   CTD; 127247; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005864; -.
DR   VGNC; VGNC:26194; ASB17.
DR   eggNOG; ENOG502QVW2; Eukaryota.
DR   GeneTree; ENSGT00390000018077; -.
DR   InParanoid; Q32KY8; -.
DR   OMA; ITIRTQL; -.
DR   OrthoDB; 1152713at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000005864; Expressed in semen and 10 other tissues.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039147; ASB17.
DR   InterPro; IPR001496; SOCS_box.
DR   PANTHER; PTHR20966; PTHR20966; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..295
FT                   /note="Ankyrin repeat and SOCS box protein 17"
FT                   /id="PRO_0000283060"
FT   REPEAT          146..176
FT                   /note="ANK"
FT   DOMAIN          232..295
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   295 AA;  34253 MW;  A06CEE8E3F4CAFE8 CRC64;
     MSKSSKLCCK TSCPRSNIFC SLVDKVFKRP SLQSLHQWGY HCYEPRVYRT LAKILRYVDL
     EGFDILLSDY IAFVEKSGCH LEVNFNLEFT EICVNTILYW VFARKGNPDF VELLLKKTKD
     YVQDRSFNLA LIWRTFTPVY CPSPLSGITP LLYVAQTRQS NILKILLQYG ILERENNPIN
     IVLTILLYPS RVRIMVDHEL VDIEEDAKTC LVLCSRVLST ISIREIEMQL SLGRRPIISN
     WLDYIPSTRY KDPCELLHLC RITIRAQLLT NNMLPNGIFS LLIPVCLQNY LNLES