ID   ASB17_CANLF             Reviewed;         295 AA.
AC   Q8HYV8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE            Short=ASB-17;
GN   Name=ASB17;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Guo J.H., Yu L.;
RT   "Cloning of a novel human testis specific gene ASB-17.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ518867; CAD57679.1; -; mRNA.
DR   STRING; 9612.ENSCAFP00000030238; -.
DR   PaxDb; Q8HYV8; -.
DR   eggNOG; ENOG502QVW2; Eukaryota.
DR   InParanoid; Q8HYV8; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039147; ASB17.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR20966; PTHR20966; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..295
FT                   /note="Ankyrin repeat and SOCS box protein 17"
FT                   /id="PRO_0000066958"
FT   REPEAT          146..176
FT                   /note="ANK"
FT   DOMAIN          232..295
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   295 AA;  34398 MW;  006BD6703630DA88 CRC64;
     MSKSSKLCRK TSCPRSNIFC NLIDKIVKRP SLQFLGQWGY HCYEPRIYRT LAKILRYVDL
     DGFDILLSDY IAFVEKSGYR FELNFNLEFT EICVNTILYW VFARKGNPDF VELLLKKTKD
     YVQDRSCNLA LIWRTFTPVY CPSPLSGITP LLYVAQTRQS NILKILLQYG ILEREKNPIN
     IVITILLYPS RVRIMVDHEL VDIQEDAKTC LVLCSRVLSA ISIREIETQL SLGRRPIISN
     WLDYIPSTRY KDPCELSHLC RITIRAQLLT NNMLPNGIFS LQIPXRLQKY LNLES