ASB17_HUMAN
ID ASB17_HUMAN Reviewed; 295 AA.
AC Q8WXJ9; B1APB8; Q8N0X5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE Short=ASB-17;
GN Name=ASB17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15204681; DOI=10.1080/01485010490425485;
RA Guo J.H., Saiyin H., Wei Y.H., Chen S., Chen L., Bi G., Ma L.J., Zhou G.J.,
RA Huang C.Q., Yu L., Dai L.;
RT "Expression of testis specific ankyrin repeat and SOCS box-containing 17
RT gene.";
RL Arch. Androl. 50:155-161(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-231.
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis. Not detected in
CC other tissues tested. {ECO:0000269|PubMed:15204681}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AK098606; BAC05350.1; -; mRNA.
DR EMBL; AF429968; AAN85310.1; -; mRNA.
DR EMBL; AC092813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06391.1; -; Genomic_DNA.
DR EMBL; BC036573; AAH36573.1; -; mRNA.
DR EMBL; AF403035; AAL57354.1; -; mRNA.
DR CCDS; CCDS671.1; -.
DR RefSeq; NP_543144.1; NM_080868.2.
DR AlphaFoldDB; Q8WXJ9; -.
DR BioGRID; 126044; 23.
DR IntAct; Q8WXJ9; 1.
DR STRING; 9606.ENSP00000284142; -.
DR iPTMnet; Q8WXJ9; -.
DR PhosphoSitePlus; Q8WXJ9; -.
DR BioMuta; ASB17; -.
DR DMDM; 38372883; -.
DR MassIVE; Q8WXJ9; -.
DR PaxDb; Q8WXJ9; -.
DR PeptideAtlas; Q8WXJ9; -.
DR PRIDE; Q8WXJ9; -.
DR Antibodypedia; 46911; 148 antibodies from 23 providers.
DR DNASU; 127247; -.
DR Ensembl; ENST00000284142.7; ENSP00000284142.6; ENSG00000154007.7.
DR GeneID; 127247; -.
DR KEGG; hsa:127247; -.
DR MANE-Select; ENST00000284142.7; ENSP00000284142.6; NM_080868.3; NP_543144.1.
DR UCSC; uc001dhe.2; human.
DR CTD; 127247; -.
DR GeneCards; ASB17; -.
DR HGNC; HGNC:19769; ASB17.
DR HPA; ENSG00000154007; Tissue enriched (testis).
DR neXtProt; NX_Q8WXJ9; -.
DR OpenTargets; ENSG00000154007; -.
DR PharmGKB; PA134958560; -.
DR VEuPathDB; HostDB:ENSG00000154007; -.
DR eggNOG; ENOG502QVW2; Eukaryota.
DR GeneTree; ENSGT00390000018077; -.
DR HOGENOM; CLU_082443_0_0_1; -.
DR InParanoid; Q8WXJ9; -.
DR OMA; ITIRTQL; -.
DR OrthoDB; 1152713at2759; -.
DR PhylomeDB; Q8WXJ9; -.
DR TreeFam; TF337448; -.
DR PathwayCommons; Q8WXJ9; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8WXJ9; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 127247; 14 hits in 1099 CRISPR screens.
DR ChiTaRS; ASB17; human.
DR GenomeRNAi; 127247; -.
DR Pharos; Q8WXJ9; Tbio.
DR PRO; PR:Q8WXJ9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WXJ9; protein.
DR Bgee; ENSG00000154007; Expressed in sperm and 26 other tissues.
DR Genevisible; Q8WXJ9; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039147; ASB17.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR20966; PTHR20966; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..295
FT /note="Ankyrin repeat and SOCS box protein 17"
FT /id="PRO_0000066959"
FT REPEAT 146..176
FT /note="ANK"
FT DOMAIN 232..295
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VARIANT 2
FT /note="S -> N (in dbSNP:rs3795251)"
FT /id="VAR_024174"
FT VARIANT 101
FT /note="V -> A (in dbSNP:rs1796814)"
FT /id="VAR_048288"
SQ SEQUENCE 295 AA; 34282 MW; D2F9F2C54CF2BF7F CRC64;
MSKSTKLCGK TSCPRSNIFC NLLDKIVKRP SLQFLGQWGY HCYEPRIYRS LAKILRYVDL
DGFDALLTDY IAFVEKSGYR FEVSFNLDFT EICVNTILYW VFARKGNPDF VELLLKKTKD
YVQDRSCNLA LIWRTFTPVY CPSPLSGITP LFYVAQTRQS NIFKILLQYG ILEREKNPIN
IVLTIVLYPS RVRVMVDREL ADIHEDAKTC LVLCSRVLSV ISVKEIKTQL SLGRHPIISN
WFDYIPSTRY KDPCELLHLC RLTIRNQLLT NNMLPDGIFS LLIPARLQNY LNLEI
