ID   ASB17_MACFA             Reviewed;         295 AA.
AC   Q95LR4;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE            Short=ASB-17;
GN   Name=ASB17; ORFNames=QtsA-19788;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; AB071128; BAB64522.1; -; mRNA.
DR   RefSeq; NP_001306291.1; NM_001319362.1.
DR   AlphaFoldDB; Q95LR4; -.
DR   SMR; Q95LR4; -.
DR   STRING; 9541.XP_005543045.1; -.
DR   GeneID; 102125664; -.
DR   CTD; 127247; -.
DR   eggNOG; ENOG502QVW2; Eukaryota.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039147; ASB17.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR20966; PTHR20966; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..295
FT                   /note="Ankyrin repeat and SOCS box protein 17"
FT                   /id="PRO_0000066960"
FT   REPEAT          146..176
FT                   /note="ANK"
FT   DOMAIN          232..295
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   295 AA;  34513 MW;  631203ACD2348B08 CRC64;
     MSKSNKLCRK TSCPRSNIFC NLLDKIVKRP SLQFLGQWGY HCYEPRIYRS LAKILRYVDL
     DGFDALLTDY IAFVEKSRYR FEVSFNLDFT EICVNTILYW VFARKGNPDF VELLLKKTKD
     YVQDRSCNLA LIWRTFTPVY CPSPLSGITP LFYVAQTRQS NIFKILLQYG ILEREKNPIN
     IVLTIVLYPS RVRVMVDREL ADIHEDAKTC LVLCSRVLSV ISVKEIKTQL SLGRRPIISN
     WFDYIPSTRY KDPCELLHLC RLTIRNQLLT NNMLPDGIFS LLIPARLQNY LNLEI