ID   ASB17_MOUSE             Reviewed;         295 AA.
AC   Q8VHP9; Q9CUF9;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE            Short=ASB-17;
GN   Name=Asb17;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Kile B.T., Hilton D.J., Nicola N.A.;
RT   "SOCS box proteins.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-172.
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15204681; DOI=10.1080/01485010490425485;
RA   Guo J.H., Saiyin H., Wei Y.H., Chen S., Chen L., Bi G., Ma L.J., Zhou G.J.,
RA   Huang C.Q., Yu L., Dai L.;
RT   "Expression of testis specific ankyrin repeat and SOCS box-containing 17
RT   gene.";
RL   Arch. Androl. 50:155-161(2004).
RN   [5]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15460110; DOI=10.1017/s0967199404002722;
RA   Kim K.S., Kim M.S., Kim S.K., Baek K.H.;
RT   "Murine Asb-17 expression during mouse testis development and
RT   spermatogenesis.";
RL   Zygote 12:151-156(2004).
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis (PubMed:15460110).
CC       Localizes to spermatogenic cells in testis, with highest expression in
CC       round spermatids and condensing spermatids and lower expression in
CC       pachytene spermatocytes (PubMed:15204681, PubMed:15460110).
CC       {ECO:0000269|PubMed:15204681, ECO:0000269|PubMed:15460110}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in testis from 3 weeks of age onwards,
CC       reaching maximum levels by 4 to 5 weeks of age.
CC       {ECO:0000269|PubMed:15204681, ECO:0000269|PubMed:15460110}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; AF425641; AAL60518.1; -; mRNA.
DR   EMBL; BC049572; AAH49572.1; -; mRNA.
DR   EMBL; AK016273; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS17922.1; -.
DR   RefSeq; NP_080034.2; NM_025758.4.
DR   AlphaFoldDB; Q8VHP9; -.
DR   STRING; 10090.ENSMUSP00000041293; -.
DR   PhosphoSitePlus; Q8VHP9; -.
DR   PaxDb; Q8VHP9; -.
DR   PRIDE; Q8VHP9; -.
DR   ProteomicsDB; 277247; -.
DR   Antibodypedia; 46911; 148 antibodies from 23 providers.
DR   Ensembl; ENSMUST00000044089; ENSMUSP00000041293; ENSMUSG00000038997.
DR   GeneID; 66772; -.
DR   KEGG; mmu:66772; -.
DR   UCSC; uc008rty.1; mouse.
DR   CTD; 127247; -.
DR   MGI; MGI:1914022; Asb17.
DR   VEuPathDB; HostDB:ENSMUSG00000038997; -.
DR   eggNOG; ENOG502QVW2; Eukaryota.
DR   GeneTree; ENSGT00390000018077; -.
DR   HOGENOM; CLU_082443_0_0_1; -.
DR   InParanoid; Q8VHP9; -.
DR   OMA; ITIRTQL; -.
DR   OrthoDB; 1152713at2759; -.
DR   PhylomeDB; Q8VHP9; -.
DR   TreeFam; TF337448; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 66772; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q8VHP9; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q8VHP9; protein.
DR   Bgee; ENSMUSG00000038997; Expressed in seminiferous tubule of testis and 25 other tissues.
DR   ExpressionAtlas; Q8VHP9; baseline and differential.
DR   Genevisible; Q8VHP9; MM.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039147; ASB17.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR20966; PTHR20966; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..295
FT                   /note="Ankyrin repeat and SOCS box protein 17"
FT                   /id="PRO_0000066961"
FT   REPEAT          146..176
FT                   /note="ANK"
FT   DOMAIN          243..295
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   295 AA;  34471 MW;  6FC0A4C55E4181AE CRC64;
     MNNSSKLCRK TSFPRSNIFC NLVDKIVKRP SLQFLGQWGY HCYEPRIYRT LAKILRYVDL
     DGFDILLTDY IAFVEKSGHR FELNFNLEFT EICVNTILYW VFARKGNPDF VELLLKKTKD
     YVQDRSCSLA LIWRTFTPVY CPSPLSGITP LLYVAQTRQS NILKILLQYG ILEREKNPIN
     IVLTILLYPS RVRIMVDHEL IDIQEDAKTC LMLCSRVLST ISVREIETQL SLGRRPIIQN
     WLDYIPPTRY KDPCELVHLC RITIRTQLLA NNMLPNGIFS LLIPTRLQNF LNLES