ORN_STRCO
ID ORN_STRCO Reviewed; 200 AA.
AC P57666; Q9KWH7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Oligoribonuclease {ECO:0000255|HAMAP-Rule:MF_00045};
DE EC=3.1.15.- {ECO:0000255|HAMAP-Rule:MF_00045};
GN Name=orn {ECO:0000255|HAMAP-Rule:MF_00045}; Synonyms=ornA;
GN OrderedLocusNames=SCO2793; ORFNames=2SCC13.01;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=A3(2) / M130;
RX PubMed=10913103; DOI=10.1128/jb.182.16.4647-4653.2000;
RA Ohnishi Y., Nishiyama Y., Sato R., Kameyama S., Horinouchi S.;
RT "An oligoribonuclease gene in Streptomyces griseus.";
RL J. Bacteriol. 182:4647-4653(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC oligoribonucleotides.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00045}.
CC -!- SIMILARITY: Belongs to the oligoribonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00045}.
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DR EMBL; AB036424; BAB03461.1; -; Genomic_DNA.
DR EMBL; AL939114; CAC10102.1; -; Genomic_DNA.
DR RefSeq; NP_627023.1; NC_003888.3.
DR RefSeq; WP_003976007.1; NZ_VNID01000010.1.
DR AlphaFoldDB; P57666; -.
DR SMR; P57666; -.
DR STRING; 100226.SCO2793; -.
DR GeneID; 1098227; -.
DR KEGG; sco:SCO2793; -.
DR PATRIC; fig|100226.15.peg.2850; -.
DR eggNOG; COG1949; Bacteria.
DR HOGENOM; CLU_064761_3_0_11; -.
DR InParanoid; P57666; -.
DR OMA; AFFHYRN; -.
DR PhylomeDB; P57666; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06135; Orn; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR HAMAP; MF_00045; Oligoribonuclease; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR022894; Oligoribonuclease.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11046; PTHR11046; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..200
FT /note="Oligoribonuclease"
FT /id="PRO_0000111073"
FT DOMAIN 5..169
FT /note="Exonuclease"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT ACT_SITE 126
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
SQ SEQUENCE 200 AA; 22022 MW; 9E8E89B0995EF577 CRC64;
MNDRMVWIDC EMTGLSLSDD ALIEVAALVT DSELNILGEG VDIVIRPPER ALETMPEVVR
EMHTASGLLA ELDGGTTLAD AEAQVLAYVR EHVKEPGKAP LCGNSVGTDR GFLLRDMATL
EGYLHYRIVD VSSIKELARR WYPRAYFNSP EKNGNHRALA DIRESIAELR YYREAVFVPQ
PGPDSDTARA IAAKHVVSAG
