ID   ORN_STRGR               Reviewed;         201 AA.
AC   P57667; Q9S165;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Oligoribonuclease {ECO:0000255|HAMAP-Rule:MF_00045};
DE            EC=3.1.15.- {ECO:0000255|HAMAP-Rule:MF_00045};
GN   Name=orn {ECO:0000255|HAMAP-Rule:MF_00045}; Synonyms=ornA;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IFO 13350 / CBS 651.72;
RX   PubMed=10540289; DOI=10.1046/j.1365-2958.1999.01579.x;
RA   Ohnishi Y., Kameyama S., Onaka H., Horinouchi S.;
RT   "The A-factor regulatory cascade leading to streptomycin biosynthesis in
RT   Streptomyces griseus: identification of a target gene of the A-factor
RT   receptor.";
RL   Mol. Microbiol. 34:102-111(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=IFO 13350 / CBS 651.72;
RX   PubMed=10913103; DOI=10.1128/jb.182.16.4647-4653.2000;
RA   Ohnishi Y., Nishiyama Y., Sato R., Kameyama S., Horinouchi S.;
RT   "An oligoribonuclease gene in Streptomyces griseus.";
RL   J. Bacteriol. 182:4647-4653(2000).
CC   -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC       oligoribonucleotides.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00045}.
CC   -!- SIMILARITY: Belongs to the oligoribonuclease family.
CC       {ECO:0000255|HAMAP-Rule:MF_00045}.
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DR   EMBL; AB023785; BAA86266.1; -; Genomic_DNA.
DR   PIR; T44489; T44489.
DR   RefSeq; WP_003968986.1; NZ_UAVD01000025.1.
DR   AlphaFoldDB; P57667; -.
DR   SMR; P57667; -.
DR   STRING; 1911.GCA_001715295_04187; -.
DR   GeneID; 6210023; -.
DR   OMA; AFFHYRN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd06135; Orn; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00045; Oligoribonuclease; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR022894; Oligoribonuclease.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR11046; PTHR11046; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..201
FT                   /note="Oligoribonuclease"
FT                   /id="PRO_0000111074"
FT   DOMAIN          5..169
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT   ACT_SITE        126
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
SQ   SEQUENCE   201 AA;  22149 MW;  9436B4DA313B2D65 CRC64;
     MNDRMVWIDC EMTGLSLADD ALIEVAALVT DSELNVLGEG VDIVIRPPDA ALETMPEVVR
     QMHTASGLLD ELAGGTTLAD AEEQVLAYVR EHVKEPGKAP LCGNSVGTDR GFLARDMREL
     EGYLHYRIVD VSSVKELARR WYPRAYFNSP AKNGNHRALA DIRDSITELR YYREAVFVPQ
     PGPDSERAKE IAARLSAPAA P