ORN_TROWT
ID ORN_TROWT Reviewed; 184 AA.
AC Q83GA7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Oligoribonuclease {ECO:0000255|HAMAP-Rule:MF_00045};
DE EC=3.1.15.- {ECO:0000255|HAMAP-Rule:MF_00045};
GN Name=orn {ECO:0000255|HAMAP-Rule:MF_00045}; OrderedLocusNames=TWT_406;
OS Tropheryma whipplei (strain Twist) (Whipple's bacillus).
OC Bacteria; Actinobacteria; Micrococcales; Tropherymataceae; Tropheryma.
OX NCBI_TaxID=203267;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Twist;
RX PubMed=12902375; DOI=10.1101/gr.1474603;
RA Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M.,
RA Claverie J.-M.;
RT "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a
RT reduced genome.";
RL Genome Res. 13:1800-1809(2003).
CC -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC oligoribonucleotides. {ECO:0000255|HAMAP-Rule:MF_00045}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00045}.
CC -!- SIMILARITY: Belongs to the oligoribonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00045}.
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DR EMBL; AE014184; AAO44503.1; -; Genomic_DNA.
DR RefSeq; WP_011102557.1; NC_004572.3.
DR AlphaFoldDB; Q83GA7; -.
DR SMR; Q83GA7; -.
DR STRING; 203267.TWT_406; -.
DR EnsemblBacteria; AAO44503; AAO44503; TWT_406.
DR KEGG; twh:TWT_406; -.
DR eggNOG; COG1949; Bacteria.
DR HOGENOM; CLU_064761_3_0_11; -.
DR OMA; AFFHYRN; -.
DR OrthoDB; 1390327at2; -.
DR Proteomes; UP000002200; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06135; Orn; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR HAMAP; MF_00045; Oligoribonuclease; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR022894; Oligoribonuclease.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11046; PTHR11046; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..184
FT /note="Oligoribonuclease"
FT /id="PRO_0000111076"
FT DOMAIN 10..172
FT /note="Exonuclease"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT ACT_SITE 129
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
SQ SEQUENCE 184 AA; 20196 MW; A255EFD5F4CA5783 CRC64;
MCVAPTPSHL VWVDCEMTGL NPERDELLEV AVVVTDKDLL PLDEGVNVVV SPSSEALGAM
DNYVARMHRV SGLLDELSNG VPVSEAQAMV KEYITKHVKT GGIMSGNSIA TDRLFITRYM
PDVHAILHYR MIDVSSIKEL AVRWAPEIYS GAPNKKGGHR AMADVLESIA ELAYYREHFL
TGTA