ID   ORN_VIBCH               Reviewed;         181 AA.
AC   Q9KV17;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Oligoribonuclease {ECO:0000255|HAMAP-Rule:MF_00045};
DE            EC=3.1.15.- {ECO:0000255|HAMAP-Rule:MF_00045};
GN   Name=orn {ECO:0000255|HAMAP-Rule:MF_00045}; OrderedLocusNames=VC_0341;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: 3'-to-5' exoribonuclease specific for small
CC       oligoribonucleotides. {ECO:0000255|HAMAP-Rule:MF_00045}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00045}.
CC   -!- SIMILARITY: Belongs to the oligoribonuclease family.
CC       {ECO:0000255|HAMAP-Rule:MF_00045}.
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DR   EMBL; AE003852; AAF93514.1; -; Genomic_DNA.
DR   PIR; E82333; E82333.
DR   RefSeq; NP_229995.1; NC_002505.1.
DR   RefSeq; WP_000010183.1; NZ_LT906614.1.
DR   PDB; 6N6D; X-ray; 1.53 A; A=1-181.
DR   PDB; 6N6E; X-ray; 1.58 A; A=1-181.
DR   PDB; 6N6F; X-ray; 1.74 A; A=1-181.
DR   PDB; 6N6G; X-ray; 2.02 A; A=1-181.
DR   PDB; 6N6H; X-ray; 1.76 A; A=1-181.
DR   PDB; 7V5H; X-ray; 1.70 A; A=1-181.
DR   PDBsum; 6N6D; -.
DR   PDBsum; 6N6E; -.
DR   PDBsum; 6N6F; -.
DR   PDBsum; 6N6G; -.
DR   PDBsum; 6N6H; -.
DR   PDBsum; 7V5H; -.
DR   AlphaFoldDB; Q9KV17; -.
DR   SMR; Q9KV17; -.
DR   STRING; 243277.VC_0341; -.
DR   DNASU; 2615077; -.
DR   EnsemblBacteria; AAF93514; AAF93514; VC_0341.
DR   KEGG; vch:VC_0341; -.
DR   PATRIC; fig|243277.26.peg.318; -.
DR   eggNOG; COG1949; Bacteria.
DR   HOGENOM; CLU_064761_2_0_6; -.
DR   OMA; AFFHYRN; -.
DR   BioCyc; VCHO:VC0341-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd06135; Orn; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00045; Oligoribonuclease; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR022894; Oligoribonuclease.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR11046; PTHR11046; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Exonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..181
FT                   /note="Oligoribonuclease"
FT                   /id="PRO_0000111077"
FT   DOMAIN          8..171
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT   ACT_SITE        129
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00045"
FT   STRAND          8..18
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   TURN            20..22
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   STRAND          25..33
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   STRAND          39..47
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           52..55
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           60..68
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           71..77
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           82..93
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   TURN            94..96
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   TURN            99..101
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   STRAND          104..108
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           109..119
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           121..124
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   STRAND          131..133
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           134..144
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           146..151
FT                   /evidence="ECO:0007829|PDB:6N6D"
FT   HELIX           160..177
FT                   /evidence="ECO:0007829|PDB:6N6D"
SQ   SEQUENCE   181 AA;  20929 MW;  AAC071B9C94FEFE3 CRC64;
     MSFSDQNLIW IDLEMTGLDP EMHKIIEMAT IVTDSELNIL AEGPVIAIHQ PESELAKMDE
     WCTTTHTASG LVARVRQSQV SEEEAIDQTL AFLKQWVPEG KSPICGNSIG QDRRFLYKHM
     PRLEAYFHYR YIDVSTIKEL TRRWQPEVLK EFSKTGSHLA LDDIRESIAE LQFYRKAVFK
     I