ASB18_MOUSE
ID ASB18_MOUSE Reviewed; 467 AA.
AC Q8VHA6; Q3B7Y5; Q3KNB0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Ankyrin repeat and SOCS box protein 18;
DE Short=ASB-18;
GN Name=Asb18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RA Kile B.T., Hilton D.J., Nicola N.A.;
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VHA6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VHA6-2; Sequence=VSP_029624, VSP_029626, VSP_029627;
CC Name=3;
CC IsoId=Q8VHA6-3; Sequence=VSP_029624, VSP_029625;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AY057054; AAL18249.1; -; mRNA.
DR EMBL; BC107370; AAI07371.1; -; mRNA.
DR EMBL; BC107371; AAI07372.1; -; mRNA.
DR EMBL; BC127152; AAI27153.1; -; mRNA.
DR CCDS; CCDS15151.1; -. [Q8VHA6-1]
DR RefSeq; NP_631891.1; NM_139152.1. [Q8VHA6-1]
DR AlphaFoldDB; Q8VHA6; -.
DR SMR; Q8VHA6; -.
DR STRING; 10090.ENSMUSP00000084095; -.
DR PhosphoSitePlus; Q8VHA6; -.
DR PaxDb; Q8VHA6; -.
DR PRIDE; Q8VHA6; -.
DR ProteomicsDB; 277248; -. [Q8VHA6-1]
DR Antibodypedia; 63013; 10 antibodies from 6 providers.
DR DNASU; 208372; -.
DR Ensembl; ENSMUST00000086882; ENSMUSP00000084095; ENSMUSG00000067081. [Q8VHA6-1]
DR Ensembl; ENSMUST00000154228; ENSMUSP00000117767; ENSMUSG00000067081. [Q8VHA6-2]
DR GeneID; 208372; -.
DR KEGG; mmu:208372; -.
DR UCSC; uc007bzd.1; mouse. [Q8VHA6-1]
DR CTD; 401036; -.
DR MGI; MGI:2655109; Asb18.
DR VEuPathDB; HostDB:ENSMUSG00000067081; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000162056; -.
DR HOGENOM; CLU_035721_2_0_1; -.
DR InParanoid; Q8VHA6; -.
DR OMA; KPLQNYV; -.
DR OrthoDB; 540084at2759; -.
DR PhylomeDB; Q8VHA6; -.
DR TreeFam; TF323921; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 208372; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8VHA6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8VHA6; protein.
DR Bgee; ENSMUSG00000067081; Expressed in hindlimb stylopod muscle and 31 other tissues.
DR ExpressionAtlas; Q8VHA6; baseline and differential.
DR Genevisible; Q8VHA6; MM.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037341; ASB18.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24118:SF76; PTHR24118:SF76; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..467
FT /note="Ankyrin repeat and SOCS box protein 18"
FT /id="PRO_0000311876"
FT REPEAT 15..45
FT /note="ANK 1"
FT REPEAT 57..87
FT /note="ANK 2"
FT REPEAT 119..148
FT /note="ANK 3"
FT REPEAT 151..180
FT /note="ANK 4"
FT REPEAT 184..213
FT /note="ANK 5"
FT REPEAT 218..247
FT /note="ANK 6"
FT REPEAT 251..292
FT /note="ANK 7"
FT REPEAT 293..322
FT /note="ANK 8"
FT REPEAT 326..362
FT /note="ANK 9"
FT DOMAIN 406..464
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VAR_SEQ 69..109
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029624"
FT VAR_SEQ 123..345
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029625"
FT VAR_SEQ 200
FT /note="C -> F (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029626"
FT VAR_SEQ 201..467
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029627"
SQ SEQUENCE 467 AA; 50700 MW; B451A333B4A9D39B CRC64;
MSSWDSPPDY PLSSDIVRRL KSALATGDED TVQKLICTEV EPVDAVIELA NDDWMKEPSA
ELPTGVLLGD LDHIRLLMDQ CFWDANAVFE ISNGEMEWQV TSLATFGLSG LWTLEYQREL
TTPLCIAAAH GHESCVRHLL SRKADPNASP GGRGALHEAC LGNHTACARL LLQHGADPDL
LNSEGLAPLH LCRTPASLGC ARELLEHGAT VQLEGGPGRD TPLHVAAQRG LDEHAQLYLG
FGARVDARNG RGETALSAAC GAAARSPDEH ARCLRLCALL LRGGAAADAR DEDERSPLHK
ACGHARPGLC TLLLRHGADA GALDYGGASP LARALQTATC APPTAPQRTV QVLLNHGSRS
VWPDAFPKVL RTCAQVPEVI EVLFNSYTQL PVSESWREAI PEEVYQMHKP FYRSLFALAH
TPRCLQHLCR CTIRKLFGKE SVHLVPQLPL PETLQNYLLL EPEGVLC
