ID   ORP1A_ARATH             Reviewed;         760 AA.
AC   O80866;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Oxysterol-binding protein-related protein 1A;
DE   AltName: Full=OSBP-related protein 1A;
GN   Name=ORP1A; OrderedLocusNames=At2g31020; ORFNames=F7F1.23;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA   Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT   "Identification and characterization of PiORP1, a Petunia oxysterol-
RT   binding-protein related protein involved in receptor-kinase mediated
RT   signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL   Plant Mol. Biol. 61:553-565(2006).
CC   -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots and at lower levels in stems.
CC       {ECO:0000269|PubMed:16897474}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AC004669; AAC20736.1; -; Genomic_DNA.
DR   EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; E84715; E84715.
DR   AlphaFoldDB; O80866; -.
DR   SMR; O80866; -.
DR   STRING; 3702.AT2G31020.1; -.
DR   PaxDb; O80866; -.
DR   PRIDE; O80866; -.
DR   ProteomicsDB; 248770; -.
DR   EnsemblPlants; AT2G31020.1; AT2G31020.1; AT2G31020.
DR   Gramene; AT2G31020.1; AT2G31020.1; AT2G31020.
DR   Araport; AT2G31020; -.
DR   TAIR; locus:2052801; AT2G31020.
DR   eggNOG; KOG1737; Eukaryota.
DR   HOGENOM; CLU_007105_0_1_1; -.
DR   InParanoid; O80866; -.
DR   PhylomeDB; O80866; -.
DR   PRO; PR:O80866; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O80866; baseline and differential.
DR   Genevisible; O80866; AT.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Lipid transport; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..760
FT                   /note="Oxysterol-binding protein-related protein 1A"
FT                   /id="PRO_0000402156"
FT   DOMAIN          70..203
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          287..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..501
FT                   /note="Conserved"
FT   COILED          268..322
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        302..323
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  87319 MW;  0E43323306BAF69C CRC64;
     MYAATPETPF GSARSQPVIT RSVSQRYNHP GQSNHHHLLH SLSFNHQNVL ALPAAAREPP
     VDVKINDIAG NSIAGILYKW VNYGKGWRPR WFVLQDGVLS YYKIKGPDKI VVIHETEKGS
     RVIGEESTRM ISRNKRHAAT NNTNHQLRRK PFGEVHLKVS SIRESRSDDK RFSIFTGTKR
     LHLRAETRED REAWIEALQA VKDMFPRMSN CELMAPTNNL DISIEKLRLR LVEEGVSESA
     IQDCEQITRS EFSAIQSQLL LLKQKQWLLI DTLRQLETEK VDLENTVVDE TQRQAGNGDS
     EETISESDDD NEQFDEAEEE MDTCDSLSSS SFKSIGSVFR TSSFSSDDDG LTNGFESEND
     DVDPSIKTIG FNYPHVKRRK KLPDPVEKEK SVSLWSMIKD NIGKDLTKVC LPVYFNEPLS
     SLQKCFEDLE YSYLLDQASE WGKRGNNLMR ILNVAAFAVS GYASTEGRIC KPFNPMLGET
     YEADYPDKGL RFFSEKVSHH PMIVACHCDG TGWKFWGDSN LKSKFWGRSI QLDPIGLLTL
     QFDDGEIVQW SKVTTSIYNL ILGKLYCDHY GTMKIEGNGE YSCKLKFKEQ SMIDRNPHQV
     QGIVEDKNGK TVARLFGKWD ESIHYVMVDQ GKVNESHLLW KRNKQPENPT KYNLTRFGIT
     LNELTPGLKE KLPPTDSRLR PDQRYLEKGE YEMGNAEKLR LEQRQRQARE MQERGWKPKW
     FRKEKGSETY RYIGGYWEAR DSGSWDDCPD IFGQVHQSIK