ORP1C_ARATH
ID ORP1C_ARATH Reviewed; 814 AA.
AC Q8L751; Q3E6U4; Q56XA3; Q56ZH2; Q9SUG2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Oxysterol-binding protein-related protein 1C;
DE AltName: Full=OSBP-related protein 1C;
GN Name=ORP1C; OrderedLocusNames=At4g08180; ORFNames=T12G13.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 413-814 AND 742-814.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT "Identification and characterization of PiORP1, a Petunia oxysterol-
RT binding-protein related protein involved in receptor-kinase mediated
RT signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL Plant Mol. Biol. 61:553-565(2006).
CC -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8L751-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8L751-2; Sequence=VSP_040247, VSP_040248;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers and
CC pollen. {ECO:0000269|PubMed:16897474}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD94620.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BX826423; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=CAB45788.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81154.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL080252; CAB45788.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161510; CAB81154.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82605.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82606.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66076.1; -; Genomic_DNA.
DR EMBL; AY139750; AAM98072.1; -; mRNA.
DR EMBL; BX826423; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK220993; BAD94620.1; ALT_INIT; mRNA.
DR EMBL; AK221773; BAD93875.1; -; mRNA.
DR PIR; T10545; T10545.
DR RefSeq; NP_001319881.1; NM_001340578.1. [Q8L751-1]
DR RefSeq; NP_192558.2; NM_116887.3. [Q8L751-1]
DR RefSeq; NP_974518.1; NM_202789.1. [Q8L751-2]
DR AlphaFoldDB; Q8L751; -.
DR SMR; Q8L751; -.
DR STRING; 3702.AT4G08180.1; -.
DR iPTMnet; Q8L751; -.
DR PaxDb; Q8L751; -.
DR PRIDE; Q8L751; -.
DR ProteomicsDB; 248736; -. [Q8L751-1]
DR EnsemblPlants; AT4G08180.1; AT4G08180.1; AT4G08180. [Q8L751-1]
DR EnsemblPlants; AT4G08180.3; AT4G08180.3; AT4G08180. [Q8L751-2]
DR EnsemblPlants; AT4G08180.4; AT4G08180.4; AT4G08180. [Q8L751-1]
DR GeneID; 826368; -.
DR Gramene; AT4G08180.1; AT4G08180.1; AT4G08180. [Q8L751-1]
DR Gramene; AT4G08180.3; AT4G08180.3; AT4G08180. [Q8L751-2]
DR Gramene; AT4G08180.4; AT4G08180.4; AT4G08180. [Q8L751-1]
DR KEGG; ath:AT4G08180; -.
DR Araport; AT4G08180; -.
DR TAIR; locus:2132492; AT4G08180.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_007105_0_1_1; -.
DR InParanoid; Q8L751; -.
DR OMA; HLPCLDT; -.
DR OrthoDB; 542090at2759; -.
DR PhylomeDB; Q8L751; -.
DR PRO; PR:Q8L751; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8L751; baseline and differential.
DR Genevisible; Q8L751; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Lipid transport; Lipid-binding;
KW Reference proteome; Transport.
FT CHAIN 1..814
FT /note="Oxysterol-binding protein-related protein 1C"
FT /id="PRO_0000402158"
FT DOMAIN 103..235
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 319..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 300..367
FT /evidence="ECO:0000255"
FT COMPBIAS 331..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 342
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040247"
FT VAR_SEQ 759..761
FT /note="ARK -> VIQ (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040248"
SQ SEQUENCE 814 AA; 92764 MW; B4F2A4382EA6130F CRC64;
MHPFCCVTTV SDHSPSMPPL PEPQPPLPNY AADFGSARSE PIITRSASQS YNHSGQFNNN
LIHSLSFNHH QSDVTDRLGQ RVLALPAAVR EPPVDVKIND IVGNGIAGIL YKWVNYGRGW
RPRWFVLQDG VLSYYKIHGP DKIFVSPETE KGSKVIGDES ARMISRHNRR GGSSSSCQLR
RKPFGEVHLK VSSVRESRSD DKRFSIFTGT KRLHLRAETR EDRTTWVEAL QAVKDMFPRM
SNSELMAPTN NLAMSTEKIR LRLIEEGVSE LAIQDCEQIM KSEFSALQSQ LVLLKQKQWL
LIDTLRQLET EKVDLENTVV DESQRQADNG CSGELRHEKF SEGTATESDD DNERGDAAEE
EFDEEENTFF DTRDFLSSSS FKSSGSGFRT SSFSSDEDGF ESEDDIDPSI KSIGCNYPRV
KRRKNLPDPV EKEKSVSLWS MIKDNIGKDL TKVCLPVYFN EPLSSLQKCF EDLEYSYLLD
RAFEYGKRGN SLMRILNVAA FAVSGYASTE GRICKPFNPL LGETYEADYP DKGLRFFSEK
VSHHPMVVAC HCDGTGWKFW GDSNLRSKFW GRSIQLDPVG VLTLQFDDGE ILQWSKVTTS
IYNLILGKLY CDHYGTMRIE GSAEYSCKLK FKEQSIIDRN PHQVHGIVQN KSGKTVATMF
GKWDESIHFV TGDCSGKGKL SEDMSGAQLL WKRSKPPGNA TKYNLTRFAI TLNELTPGLK
ERLPPTDSRL RPDQRYLENG EFEMANTEKL RLEQRQRQAR KMQERGWKPR WFMKEKGSES
YRYKGGYWEA REDGSWVDCP DIFGHIDSDQ QMIE
