ORP1D_ARATH
ID ORP1D_ARATH Reviewed; 816 AA.
AC Q9SAF0;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Oxysterol-binding protein-related protein 1D;
DE AltName: Full=OSBP-related protein 1D;
GN Name=ORP1D; OrderedLocusNames=At1g13170; ORFNames=F3F19.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT "Identification and characterization of PiORP1, a Petunia oxysterol-
RT binding-protein related protein involved in receptor-kinase mediated
RT signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL Plant Mol. Biol. 61:553-565(2006).
CC -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SAF0-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:16897474}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR EMBL; AC007357; AAD31070.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28978.1; -; Genomic_DNA.
DR EMBL; AF462814; AAL58905.1; -; mRNA.
DR PIR; A86266; A86266.
DR RefSeq; NP_172776.1; NM_101187.3. [Q9SAF0-1]
DR AlphaFoldDB; Q9SAF0; -.
DR SMR; Q9SAF0; -.
DR STRING; 3702.AT1G13170.2; -.
DR iPTMnet; Q9SAF0; -.
DR PaxDb; Q9SAF0; -.
DR PRIDE; Q9SAF0; -.
DR ProteomicsDB; 248824; -. [Q9SAF0-1]
DR EnsemblPlants; AT1G13170.1; AT1G13170.1; AT1G13170. [Q9SAF0-1]
DR GeneID; 837875; -.
DR Gramene; AT1G13170.1; AT1G13170.1; AT1G13170. [Q9SAF0-1]
DR KEGG; ath:AT1G13170; -.
DR Araport; AT1G13170; -.
DR eggNOG; KOG1737; Eukaryota.
DR InParanoid; Q9SAF0; -.
DR PhylomeDB; Q9SAF0; -.
DR PRO; PR:Q9SAF0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SAF0; baseline and differential.
DR Genevisible; Q9SAF0; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Lipid transport; Lipid-binding;
KW Reference proteome; Transport.
FT CHAIN 1..816
FT /note="Oxysterol-binding protein-related protein 1D"
FT /id="PRO_0000402159"
FT DOMAIN 92..229
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 340..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..321
FT /evidence="ECO:0000255"
FT COILED 735..764
FT /evidence="ECO:0000255"
FT COMPBIAS 348..362
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 92332 MW; C4D1EF606F03A091 CRC64;
MNPLCCIAPV SIDDRTNPVV AKSSNHHLGL EAIPVSKHAS KPSFSTQASW ISQDQLERLS
SEVVDDVNLD GKDASSSSNK GCFFFGNCVG AGAGVAGIMY KWVNYGKGWR ARWFELEDGV
LSYYKIHGPD KIVMNPSREK GVRVIGEESV RYIRKASCGS SNRLGASAVA ASRPCKPFGE
IHLKVSSIRA SKSDDKRLAI FTGTKTLHLR CVSKENRAAW VEAFQVAKDL FPRVASGDIL
PSEDAVVSTE KLREKLLQEG VGETVVKDCE AIMLSEVSVL QNRLKVLTHK HIILLDTLRQ
LETEKIELEA TVVDETKEHD SCCGQGRRFS DFYSVMSEVS ASDSEADNES QDGADVESDE
DDVPYFDTND ILSAEAMRSA SYRSREAEGN GSIYDKDPFF SDRLQIPARI PQYPYVRRRD
NLPEPKEKEK PVGLWSIIKE NIGKDLSGVC LPVYFNEPLS SLQKCFEDLE YSYLIDRALE
WGKQGNELMR ILNIAAFAVS GYASTEGRQC KPFNPLLGET YEADYPDKGL RFFSEKVSHH
PMIVACHCEG QGWNFWGDSN IKGKFWGRSI QLDPVGVLTL KFDDGEIYQW SKVTTSIYNI
ILGKLYCDHY GTMRIKGGSN YSCRLKFKEQ SVIDRNPRQV HGFVQDNRTG EKVAILIGKW
DEAMYYVLGD PTTKPKGYDP MTEAVLLWER DKSPTKTRYN LSPFAISLNE ITPGMIDKLP
PTDSRLRPDQ RHLENGEYES ANAEKLRLEQ LQRQARRLQE KGWKPRWFEK DEEGNYRYLG
GYWEAREKKD WDRITDIFKK QQQRNSLSSS SSSTFL
