位置:首页 > 蛋白库 > ORP2B_ARATH
ORP2B_ARATH
ID   ORP2B_ARATH             Reviewed;         693 AA.
AC   Q9SU36; Q8L711;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Oxysterol-binding protein-related protein 2B;
DE   AltName: Full=OSBP-related protein 2B;
GN   Name=ORP2B; OrderedLocusNames=At4g12460; ORFNames=T1P17.50;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA   Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT   "Identification and characterization of PiORP1, a Petunia oxysterol-
RT   binding-protein related protein involved in receptor-kinase mediated
RT   signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL   Plant Mol. Biol. 61:553-565(2006).
CC   -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9SU36-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9SU36-2; Sequence=VSP_040250, VSP_040251;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC       {ECO:0000269|PubMed:16897474}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB41716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB78289.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL049730; CAB41716.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161534; CAB78289.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE83135.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE83136.1; -; Genomic_DNA.
DR   EMBL; CP002687; ANM66036.1; -; Genomic_DNA.
DR   EMBL; AY140023; AAM98164.1; -; mRNA.
DR   EMBL; BT008852; AAP68291.1; -; mRNA.
DR   PIR; T07638; T07638.
DR   RefSeq; NP_001078376.1; NM_001084907.1. [Q9SU36-2]
DR   RefSeq; NP_001327962.1; NM_001340780.1. [Q9SU36-1]
DR   RefSeq; NP_001327968.1; NM_001340779.1.
DR   RefSeq; NP_192983.2; NM_117316.3. [Q9SU36-1]
DR   AlphaFoldDB; Q9SU36; -.
DR   SMR; Q9SU36; -.
DR   BioGRID; 12156; 1.
DR   IntAct; Q9SU36; 1.
DR   STRING; 3702.AT4G12460.1; -.
DR   iPTMnet; Q9SU36; -.
DR   PaxDb; Q9SU36; -.
DR   PRIDE; Q9SU36; -.
DR   ProteomicsDB; 248906; -. [Q9SU36-1]
DR   EnsemblPlants; AT4G12460.1; AT4G12460.1; AT4G12460. [Q9SU36-1]
DR   EnsemblPlants; AT4G12460.2; AT4G12460.2; AT4G12460. [Q9SU36-2]
DR   EnsemblPlants; AT4G12460.8; AT4G12460.8; AT4G12460. [Q9SU36-1]
DR   GeneID; 826858; -.
DR   Gramene; AT4G12460.1; AT4G12460.1; AT4G12460. [Q9SU36-1]
DR   Gramene; AT4G12460.2; AT4G12460.2; AT4G12460. [Q9SU36-2]
DR   Gramene; AT4G12460.8; AT4G12460.8; AT4G12460. [Q9SU36-1]
DR   KEGG; ath:AT4G12460; -.
DR   Araport; AT4G12460; -.
DR   TAIR; locus:2135580; AT4G12460.
DR   eggNOG; KOG1737; Eukaryota.
DR   HOGENOM; CLU_007105_0_1_1; -.
DR   InParanoid; Q9SU36; -.
DR   OrthoDB; 542090at2759; -.
DR   PhylomeDB; Q9SU36; -.
DR   PRO; PR:Q9SU36; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q9SU36; baseline and differential.
DR   Genevisible; Q9SU36; AT.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Lipid transport; Lipid-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..693
FT                   /note="Oxysterol-binding protein-related protein 2B"
FT                   /id="PRO_0000402161"
FT   DOMAIN          25..154
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..239
FT                   /evidence="ECO:0000255"
FT   COILED          612..643
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        603..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..326
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172"
FT                   /id="VSP_040250"
FT   VAR_SEQ         600..601
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14593172"
FT                   /id="VSP_040251"
SQ   SEQUENCE   693 AA;  79566 MW;  0FF3F23AF76C9229 CRC64;
     MPLTRSKSLP ATENGGSDRE TLQSGRSVAG ILYKWTNYGK GWRSRWFLLR DGILSYSKIR
     RPENVNLLSP SDDLRLIGDI STDRLLRMKS CSGRSRRKHH KNIGIVHLKV SSYRESKSDH
     RKFYIFTATK TLHLRTDSRS DRAAWLQALA STRGIVPLQS INGDFSFVSP KDLSISTERL
     KKRLFEEGMN ESLVKECEQI VDSEFCEVQE QIKLLHEERK KLLDALRQLE MANLEAEASG
     IHDDVYQLRN HKYSSLGRGK YSECSTSASS DDKQEFEDIS EEDEASFHDT KESFGEPDVG
     SVLTHFKRRT KLPDPAEKER GVSLWSMIKD NVGKDLTRVC LPVYFNEPIS SLQKCFEDLE
     YSYLLDQAYE YGKSGKSLLR ALNVAAFAVS GYASTEGRHC KPFNPLLGET YEADFPEKGI
     RFFSEKVSHH PTVIACHCEG KGWKFWGDTN LRSKFWGRSI QLEPVGILTL EFDDGEIFQW
     SKVTTTIYNI LLGKLYCDHH GIMKIRGNRQ YSCMLKFKEQ SILDRNPHQV NGFVEDVTGK
     KAATVFGKWN DSLYYVAGDG INKASASLLW KATKAPPNVT RYNFTSFAMT LNELIPGLEE
     KLPPTDSRLR PDQRHLENGE YEKANEEKQR LERRQRMSRQ IQESGWRPRW FEPQGESESY
     KYTGGYWEAR DVKSWDDCPN IFGEFTEEVA DCA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024