ORP3C_ARATH
ID ORP3C_ARATH Reviewed; 457 AA.
AC Q93Y40; Q9LTI7;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Oxysterol-binding protein-related protein 3C;
DE AltName: Full=OSBP-related protein 3C;
GN Name=ORP3C; OrderedLocusNames=At5g59420; ORFNames=F2O15.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT "Identification and characterization of PiORP1, a Petunia oxysterol-
RT binding-protein related protein involved in receptor-kinase mediated
RT signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL Plant Mol. Biol. 61:553-565(2006).
CC -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:16897474}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA97478.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB025604; BAA97478.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97183.1; -; Genomic_DNA.
DR EMBL; AY054473; AAK96664.1; -; mRNA.
DR EMBL; BT000115; AAN15434.1; -; mRNA.
DR RefSeq; NP_200750.1; NM_125333.5.
DR AlphaFoldDB; Q93Y40; -.
DR SMR; Q93Y40; -.
DR STRING; 3702.AT5G59420.1; -.
DR PaxDb; Q93Y40; -.
DR PRIDE; Q93Y40; -.
DR ProteomicsDB; 248647; -.
DR DNASU; 836061; -.
DR EnsemblPlants; AT5G59420.1; AT5G59420.1; AT5G59420.
DR GeneID; 836061; -.
DR Gramene; AT5G59420.1; AT5G59420.1; AT5G59420.
DR KEGG; ath:AT5G59420; -.
DR Araport; AT5G59420; -.
DR TAIR; locus:2148368; AT5G59420.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_007105_6_0_1; -.
DR InParanoid; Q93Y40; -.
DR OMA; AHSAKMY; -.
DR OrthoDB; 863978at2759; -.
DR PhylomeDB; Q93Y40; -.
DR PRO; PR:Q93Y40; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q93Y40; baseline and differential.
DR Genevisible; Q93Y40; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
DR PROSITE; PS01013; OSBP; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..457
FT /note="Oxysterol-binding protein-related protein 3C"
FT /id="PRO_0000402164"
FT REGION 37..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 51966 MW; 90DDB0654110D85D CRC64;
MGSPKKNENK GFFAAMTSGF SMFGTAVSRS VNGVQGNEGV EVINPEGGKE DAEEEAQKGR
WKDEERDSYW KMMQKYIGSD ITSMVTLPVV IFEPMTMLQK MAEIMEYSHL LDQADECEDP
YLRLVYASSW AISVYYAFQR TWKPFNPILG ETYEMVNHGG ISFISEQVSH HPPMSAGHAE
NEHFIYDITS KLKTKLLGNS VDVYPVGRTR VTLKKDGVVL DLVPPLTKIH NLIFGRTWVD
SPGEMVMTNL TTGDKVVLYF QPCGWFGSGR YEVDGYVYSA AEEPKIMMTG KWNEKMSYQP
CDAEGEPLPG TELKEVWHLA DVPKNDNFQY THFAHKINSF DTAPAKLLAS DSRIRPDRYS
LEQGDLSKAG SEKHSLEERQ RAEKRTRETK GQKFTPRWFD LTDEITPTPW GDIEVYQYNG
KYNEHRDTAE SSSSASNETD LKSIEFNPWQ YGNISTE
