ORP4A_ARATH
ID ORP4A_ARATH Reviewed; 386 AA.
AC Q9SVZ9;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Oxysterol-binding protein-related protein 4A;
DE AltName: Full=OSBP-related protein 4A;
GN Name=ORP4A; OrderedLocusNames=At4g25860; ORFNames=F14M19.140;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT "Identification and characterization of PiORP1, a Petunia oxysterol-
RT binding-protein related protein involved in receptor-kinase mediated
RT signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL Plant Mol. Biol. 61:553-565(2006).
CC -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems and flowers.
CC {ECO:0000269|PubMed:16897474}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB39607.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049480; CAB39607.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161564; CAB79441.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85125.1; -; Genomic_DNA.
DR EMBL; BX828422; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T04240; T04240.
DR RefSeq; NP_001329919.1; NM_001341766.1.
DR RefSeq; NP_194316.2; NM_118719.4.
DR AlphaFoldDB; Q9SVZ9; -.
DR SMR; Q9SVZ9; -.
DR BioGRID; 13979; 1.
DR STRING; 3702.AT4G25860.1; -.
DR TCDB; 2.D.1.1.5; the pi4p/ps counter transporter (p/p-ct) family.
DR PaxDb; Q9SVZ9; -.
DR PRIDE; Q9SVZ9; -.
DR ProteomicsDB; 248737; -.
DR EnsemblPlants; AT4G25860.1; AT4G25860.1; AT4G25860.
DR GeneID; 828692; -.
DR Gramene; AT4G25860.1; AT4G25860.1; AT4G25860.
DR KEGG; ath:AT4G25860; -.
DR Araport; AT4G25860; -.
DR TAIR; locus:2117532; AT4G25860.
DR eggNOG; KOG2210; Eukaryota.
DR HOGENOM; CLU_044270_0_0_1; -.
DR InParanoid; Q9SVZ9; -.
DR OrthoDB; 949920at2759; -.
DR PhylomeDB; Q9SVZ9; -.
DR PRO; PR:Q9SVZ9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SVZ9; baseline and differential.
DR Genevisible; Q9SVZ9; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..386
FT /note="Oxysterol-binding protein-related protein 4A"
FT /id="PRO_0000402165"
SQ SEQUENCE 386 AA; 44072 MW; FB5CE1DBC77723B9 CRC64;
MAEEEKMRRQ LVLAKPFSLE DEKDSELTAS SVIRKILSLI KTVRPGSDLT NFQLPPQLIL
PRSRLQCYGE MIYSFGGQDL LGECSRRNIP IERLKSVVTW NISTLRPVVV GMSPYNPILG
ETHHVSNGYI NVLTEQVMHH PPVSALHATH EQENIDVTWC QYFTPKFRGA YVDVEVNGKR
IMKLLHHKET YEMDQPRLIM KFLPAPGAHW AGKVKIKCPE TDLEAELHLI SDSFIERFRG
NNNRSIKGKI FESSSGNQLY NIFGHWDRTV MAKNLKTGGL EVIYNANENI TGLKPPTVKN
LQEVMESEST IVWSEVSEGI LKKDWERARE AKILVEEKQR EALKQREASG ESWVPKHFSV
VKDGKDWHCS PLQPTVPRAP LVITEK
