ORP4B_ARATH
ID ORP4B_ARATH Reviewed; 383 AA.
AC Q9SW00; Q8GXS2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Oxysterol-binding protein-related protein 4B;
DE AltName: Full=OSBP-related protein 4B;
GN Name=ORP4B; OrderedLocusNames=At4g25850; ORFNames=F14M19.130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16897474; DOI=10.1007/s11103-006-0030-y;
RA Skirpan A.L., Dowd P.E., Sijacic P., Jaworski C.J., Gilroy S., Kao T.H.;
RT "Identification and characterization of PiORP1, a Petunia oxysterol-
RT binding-protein related protein involved in receptor-kinase mediated
RT signaling in pollen, and analysis of the ORP gene family in Arabidopsis.";
RL Plant Mol. Biol. 61:553-565(2006).
CC -!- FUNCTION: May be involved in the transport of sterols. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SW00-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in stems and flowers.
CC {ECO:0000269|PubMed:16897474}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC42702.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=CAB39606.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79440.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049480; CAB39606.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161564; CAB79440.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85123.1; -; Genomic_DNA.
DR EMBL; AK118071; BAC42702.1; ALT_SEQ; mRNA.
DR EMBL; AY084235; AAM67264.1; -; mRNA.
DR PIR; T04239; T04239.
DR RefSeq; NP_001328917.1; NM_001341765.1.
DR RefSeq; NP_567732.1; NM_118718.2. [Q9SW00-1]
DR AlphaFoldDB; Q9SW00; -.
DR SMR; Q9SW00; -.
DR STRING; 3702.AT4G25850.2; -.
DR iPTMnet; Q9SW00; -.
DR PaxDb; Q9SW00; -.
DR ProteomicsDB; 226032; -. [Q9SW00-1]
DR EnsemblPlants; AT4G25850.1; AT4G25850.1; AT4G25850. [Q9SW00-1]
DR GeneID; 828691; -.
DR Gramene; AT4G25850.1; AT4G25850.1; AT4G25850. [Q9SW00-1]
DR KEGG; ath:AT4G25850; -.
DR Araport; AT4G25850; -.
DR TAIR; locus:2117522; AT4G25850.
DR eggNOG; KOG2210; Eukaryota.
DR HOGENOM; CLU_044270_0_0_1; -.
DR InParanoid; Q9SW00; -.
DR PhylomeDB; Q9SW00; -.
DR PRO; PR:Q9SW00; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SW00; baseline and differential.
DR Genevisible; Q9SW00; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Lipid transport; Lipid-binding; Reference proteome;
KW Transport.
FT CHAIN 1..383
FT /note="Oxysterol-binding protein-related protein 4B"
FT /id="PRO_0000402166"
SQ SEQUENCE 383 AA; 43674 MW; 5D7000601BBED1D9 CRC64;
MAEEEMRKHL VLAKPFSLED EKDSEHTASN VIRKILSLFK TVRPGSDLTN FQLPPQLNLP
RSQLQCYGEM VYSFVGQDLL GECSRRDLPI ERLKSVVTWN ISTLRPVVFG MSPYNSVLGE
THHVSNGHIN VIAEQVVHHP PVSALHATHE QENIDVTWCQ YFTPKFRGTH VDVEVKGKRV
MKLLNHIETY EMDQPRLIMR FLPAPGAYWA GKVKIKCPET DLEAELHLIS DSFIERFRGN
NNRSIKGKIF ESSSGNQLYN IFGHWDRTVM AKNIKTGELE VIYNAKENIT GLKPPTVKNL
EEVTESESTM VWSEVSEGIL KKDWERAREA KIVVEEKQRA SLKQREASGE SWVPKHFLVV
KDGKDWDCSP LQPTVPPAPL VIT
