ID   ORR1_ORYSJ              Reviewed;         231 AA.
AC   Q2HWG4; A0A0P0WAW6;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Two-component response regulator ORR1 {ECO:0000305};
DE   AltName: Full=OsRR1 {ECO:0000303|PubMed:16919402};
DE   AltName: Full=OsRRA9 {ECO:0000303|PubMed:16891544};
GN   Name=RR1 {ECO:0000303|PubMed:17284581};
GN   OrderedLocusNames=Os04g0442300 {ECO:0000312|EMBL:BAF14796.1},
GN   LOC_Os04g36070 {ECO:0000305};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16919402; DOI=10.1016/j.gene.2006.06.020;
RA   Ito Y., Kurata N.;
RT   "Identification and characterization of cytokinin-signalling gene families
RT   in rice.";
RL   Gene 382:57-65(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=17293362; DOI=10.1093/pcp/pcm022;
RA   Hirose N., Makita N., Kojima M., Kamada-Nobusada T., Sakakibara H.;
RT   "Overexpression of a type-A response regulator alters rice morphology and
RT   cytokinin metabolism.";
RL   Plant Cell Physiol. 48:523-539(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [6]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [8]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16891544; DOI=10.1104/pp.106.086371;
RA   Pareek A., Singh A., Kumar M., Kushwaha H.R., Lynn A.M.,
RA   Singla-Pareek S.L.;
RT   "Whole-genome analysis of Oryza sativa reveals similar architecture of two-
RT   component signaling machinery with Arabidopsis.";
RL   Plant Physiol. 142:380-397(2006).
RN   [9]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17284581; DOI=10.1104/pp.106.093666;
RA   Schaller G.E., Doi K., Hwang I., Kieber J.J., Khurana J.P., Kurata N.,
RA   Mizuno T., Pareek A., Shiu S.H., Wu P., Yip W.K.;
RT   "Nomenclature for two-component signaling elements of rice.";
RL   Plant Physiol. 143:555-557(2007).
RN   [10]
RP   FUNCTION.
RX   PubMed=21481033; DOI=10.1111/j.1365-313x.2011.04610.x;
RA   Kitomi Y., Ito H., Hobo T., Aya K., Kitano H., Inukai Y.;
RT   "The auxin responsive AP2/ERF transcription factor CROWN ROOTLESS5 is
RT   involved in crown root initiation in rice through the induction of OsRR1, a
RT   type-A response regulator of cytokinin signaling.";
RL   Plant J. 67:472-484(2011).
RN   [11]
RP   INDUCTION BY CYTOKININ.
RX   PubMed=22383541; DOI=10.1104/pp.111.192765;
RA   Tsai Y.C., Weir N.R., Hill K., Zhang W., Kim H.J., Shiu S.H.,
RA   Schaller G.E., Kieber J.J.;
RT   "Characterization of genes involved in cytokinin signaling and metabolism
RT   from rice.";
RL   Plant Physiol. 158:1666-1684(2012).
CC   -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC       phosphorelay signal transduction system. Phosphorylation of the Asp
CC       residue in the receiver domain activates the ability of the protein to
CC       promote the transcription of target genes. Type-A response regulators
CC       seem to act as negative regulators of the cytokinin signaling (By
CC       similarity). Involved in adventitious (crown) root initiation under the
CC       regulation of CRL5 (PubMed:21481033). {ECO:0000250|UniProtKB:Q9ZWS9,
CC       ECO:0000269|PubMed:21481033}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaf blades, leaf sheaths,
CC       shoot apex, flowers and panicles. {ECO:0000269|PubMed:16919402}.
CC   -!- INDUCTION: By cytokinin in roots and shoots.
CC       {ECO:0000269|PubMed:22383541}.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additional intermediate named Histidine-containing phosphotransfer
CC       protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC       Asp sequential transfer of a phosphate group between first an His and
CC       an Asp of the HK protein, followed by the transfer to a conserved His
CC       of the HPt protein and finally the transfer to an Asp in the receiver
CC       domain of the RR protein. {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Dwarf, albino, lesion mimic and low fertility
CC       phenotypes. {ECO:0000269|PubMed:16891544}.
CC   -!- MISCELLANEOUS: Crl5 mutant plants overexpressing RR1 display
CC       significantly increased adventitious (crown) root formation compared
CC       with crl5 mutant plants. {ECO:0000269|PubMed:22383541}.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BR000311; FAA00263.1; -; Genomic_DNA.
DR   EMBL; AB249661; BAE79355.1; -; mRNA.
DR   EMBL; BX548156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP008210; BAF14796.1; -; Genomic_DNA.
DR   EMBL; AP014960; BAS89358.1; -; Genomic_DNA.
DR   EMBL; AK072736; BAG93120.1; -; mRNA.
DR   EMBL; AK105815; BAG97382.1; -; mRNA.
DR   RefSeq; XP_015636992.1; XM_015781506.1.
DR   AlphaFoldDB; Q2HWG4; -.
DR   SMR; Q2HWG4; -.
DR   STRING; 4530.OS04T0442300-01; -.
DR   PaxDb; Q2HWG4; -.
DR   PRIDE; Q2HWG4; -.
DR   EnsemblPlants; Os04t0442300-01; Os04t0442300-01; Os04g0442300.
DR   EnsemblPlants; Os04t0442300-02; Os04t0442300-02; Os04g0442300.
DR   GeneID; 4335937; -.
DR   Gramene; Os04t0442300-01; Os04t0442300-01; Os04g0442300.
DR   Gramene; Os04t0442300-02; Os04t0442300-02; Os04g0442300.
DR   KEGG; osa:4335937; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_000445_69_5_1; -.
DR   InParanoid; Q2HWG4; -.
DR   OMA; AYVQISE; -.
DR   OrthoDB; 1216060at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q2HWG4; OS.
DR   GO; GO:0048830; P:adventitious root development; IMP:UniProtKB.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR045279; ARR-like.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43874; PTHR43874; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Cytokinin signaling pathway; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..231
FT                   /note="Two-component response regulator ORR1"
FT                   /id="PRO_0000433816"
FT   DOMAIN          9..135
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         68
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   231 AA;  25268 MW;  D707E37394D33EE3 CRC64;
     MEGGRGVTRV LLVDDSPVDR RVVQLLLSSS ACAGSFHVIA VDSAKKAMEF LGLKEEGKEQ
     AIDMVLTDYC MPEMTGYELL KAIKALSPLK PIPVIVMSSE NEPQRISRCM NAGAEDFIVK
     PLQSKDVQRL RNCSPANTQC CDAGSDGKPP LLLLPSDHVV VDATAASPPP PPSRRRAHFA
     GVAMVLHSSS VELSHYFPFL FKFILLVYAI LCLGELLHRW SNGCFLNLWC A