ID   ORR5_ORYSJ              Reviewed;         134 AA.
AC   Q2HWH1; A0A0P0WCT5; Q7XKF6;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Two-component response regulator ORR5 {ECO:0000305};
DE   AltName: Full=OsRR5 {ECO:0000303|PubMed:16919402};
DE   AltName: Full=OsRRA4 {ECO:0000303|PubMed:16891544};
GN   Name=RR5 {ECO:0000303|PubMed:17284581};
GN   OrderedLocusNames=Os04g0524300 {ECO:0000312|EMBL:BAF15262.1},
GN   LOC_Os04g44280 {ECO:0000305};
GN   ORFNames=OSJNBb0065J09.13 {ECO:0000312|EMBL:CAE05717.2};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16919402; DOI=10.1016/j.gene.2006.06.020;
RA   Ito Y., Kurata N.;
RT   "Identification and characterization of cytokinin-signalling gene families
RT   in rice.";
RL   Gene 382:57-65(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=17293362; DOI=10.1093/pcp/pcm022;
RA   Hirose N., Makita N., Kojima M., Kamada-Nobusada T., Sakakibara H.;
RT   "Overexpression of a type-A response regulator alters rice morphology and
RT   cytokinin metabolism.";
RL   Plant Cell Physiol. 48:523-539(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [6]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [8]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16891544; DOI=10.1104/pp.106.086371;
RA   Pareek A., Singh A., Kumar M., Kushwaha H.R., Lynn A.M.,
RA   Singla-Pareek S.L.;
RT   "Whole-genome analysis of Oryza sativa reveals similar architecture of two-
RT   component signaling machinery with Arabidopsis.";
RL   Plant Physiol. 142:380-397(2006).
RN   [9]
RP   INDUCTION BY CYTOKININ.
RX   PubMed=17408920; DOI=10.1016/j.ygeno.2007.02.001;
RA   Du L., Jiao F., Chu J., Jin G., Chen M., Wu P.;
RT   "The two-component signal system in rice (Oryza sativa L.): a genome-wide
RT   study of cytokinin signal perception and transduction.";
RL   Genomics 89:697-707(2007).
RN   [10]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17284581; DOI=10.1104/pp.106.093666;
RA   Schaller G.E., Doi K., Hwang I., Kieber J.J., Khurana J.P., Kurata N.,
RA   Mizuno T., Pareek A., Shiu S.H., Wu P., Yip W.K.;
RT   "Nomenclature for two-component signaling elements of rice.";
RL   Plant Physiol. 143:555-557(2007).
RN   [11]
RP   SUBCELLULAR LOCATION.
RX   PubMed=22383541; DOI=10.1104/pp.111.192765;
RA   Tsai Y.C., Weir N.R., Hill K., Zhang W., Kim H.J., Shiu S.H.,
RA   Schaller G.E., Kieber J.J.;
RT   "Characterization of genes involved in cytokinin signaling and metabolism
RT   from rice.";
RL   Plant Physiol. 158:1666-1684(2012).
CC   -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC       phosphorelay signal transduction system. Phosphorylation of the Asp
CC       residue in the receiver domain activates the ability of the protein to
CC       promote the transcription of target genes. Type-A response regulators
CC       seem to act as negative regulators of the cytokinin signaling.
CC       {ECO:0000250|UniProtKB:Q9ZWS9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22383541}.
CC       Nucleus {ECO:0000269|PubMed:22383541}.
CC   -!- TISSUE SPECIFICITY: Weakly expressed in flowers and panicles.
CC       {ECO:0000269|PubMed:16919402}.
CC   -!- INDUCTION: By cytokinin in roots and leaves.
CC       {ECO:0000269|PubMed:17408920}.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additional intermediate named Histidine-containing phosphotransfer
CC       protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC       Asp sequential transfer of a phosphate group between first an His and
CC       an Asp of the HK protein, followed by the transfer to a conserved His
CC       of the HPt protein and finally the transfer to an Asp in the receiver
CC       domain of the RR protein. {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Dwarf, narrow leaf, low tillering and altered
CC       kernal color phenotypes. {ECO:0000269|PubMed:16891544}.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE05717.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BR000314; FAA00266.1; -; Genomic_DNA.
DR   EMBL; AB249654; BAE79348.1; -; mRNA.
DR   EMBL; AL663010; CAE05717.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008210; BAF15262.1; -; Genomic_DNA.
DR   EMBL; AP014960; BAS90148.1; -; Genomic_DNA.
DR   EMBL; AK106426; BAG97714.1; -; mRNA.
DR   RefSeq; XP_015635282.1; XM_015779796.1.
DR   AlphaFoldDB; Q2HWH1; -.
DR   SMR; Q2HWH1; -.
DR   STRING; 4530.OS04T0524300-01; -.
DR   PaxDb; Q2HWH1; -.
DR   PRIDE; Q2HWH1; -.
DR   EnsemblPlants; Os04t0524300-01; Os04t0524300-01; Os04g0524300.
DR   GeneID; 4336439; -.
DR   Gramene; Os04t0524300-01; Os04t0524300-01; Os04g0524300.
DR   KEGG; osa:4336439; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_000445_69_5_1; -.
DR   InParanoid; Q2HWH1; -.
DR   OMA; RCMVALT; -.
DR   OrthoDB; 1311174at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q2HWH1; OS.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR045279; ARR-like.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43874; PTHR43874; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Cytokinin signaling pathway; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..134
FT                   /note="Two-component response regulator ORR5"
FT                   /id="PRO_0000433824"
FT   DOMAIN          16..133
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         66
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   134 AA;  14824 MW;  6C1E3BE2DFD5832A CRC64;
     MATCRSRGVE RGGAPHVLAV DDSSVDRAVI SGILRSSQFR VTAVDSGKRA LELLGSEPNV
     SMIITDYWMP EMTGYELLKK VKESSRLKEI PVVIMSSENV STRINRCLEE GAEDFLLKPV
     QPSDVSRLCS RVLR