ORRM2_ARATH
ID ORRM2_ARATH Reviewed; 156 AA.
AC Q9FIU6;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 152.
DE RecName: Full=Organelle RRM domain-containing protein 2, mitochondrial {ECO:0000303|PubMed:25800738};
DE Flags: Precursor;
GN Name=ORRM2 {ECO:0000303|PubMed:25800738};
GN OrderedLocusNames=At5g54580 {ECO:0000312|Araport:AT5G54580};
GN ORFNames=MRB17.8 {ECO:0000312|EMBL:BAB09337.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND INTERACTION WITH RBG3/ORRM3.
RX PubMed=25800738; DOI=10.1093/nar/gkv245;
RA Shi X., Hanson M.R., Bentolila S.;
RT "Two RNA recognition motif-containing proteins are plant mitochondrial
RT editing factors.";
RL Nucleic Acids Res. 43:3814-3825(2015).
RN [6]
RP INTERACTION WITH RBG2/ORRM5.
RC STRAIN=cv. Columbia;
RX PubMed=28549172; DOI=10.1093/jxb/erx139;
RA Shi X., Castandet B., Germain A., Hanson M.R., Bentolila S.;
RT "ORRM5, an RNA recognition motif-containing protein, has a unique effect on
RT mitochondrial RNA editing.";
RL J. Exp. Bot. 68:2833-2847(2017).
CC -!- FUNCTION: Involved in C-to-U editing of mitochondrial RNA. Functions as
CC minor mitochondrial editing factor. Controls 6 percent of the
CC mitochondrial editing sites. {ECO:0000269|PubMed:25800738}.
CC -!- SUBUNIT: Interacts with RBG3/ORRM3 (PubMed:25800738). Binds to
CC RBG2/ORRM5 (PubMed:28549172). {ECO:0000269|PubMed:25800738,
CC ECO:0000269|PubMed:28549172}.
CC -!- INTERACTION:
CC Q9FIU6; O81127: RSZ21; NbExp=3; IntAct=EBI-4449084, EBI-927172;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
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DR EMBL; AB016879; BAB09337.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96512.1; -; Genomic_DNA.
DR EMBL; AY072101; AAL59923.1; -; mRNA.
DR EMBL; AY096589; AAM20239.1; -; mRNA.
DR EMBL; AY085234; AAM62467.1; -; mRNA.
DR RefSeq; NP_200269.1; NM_124838.5.
DR AlphaFoldDB; Q9FIU6; -.
DR SMR; Q9FIU6; -.
DR IntAct; Q9FIU6; 9.
DR STRING; 3702.AT5G54580.1; -.
DR PaxDb; Q9FIU6; -.
DR PRIDE; Q9FIU6; -.
DR ProteomicsDB; 248907; -.
DR EnsemblPlants; AT5G54580.1; AT5G54580.1; AT5G54580.
DR GeneID; 835546; -.
DR Gramene; AT5G54580.1; AT5G54580.1; AT5G54580.
DR KEGG; ath:AT5G54580; -.
DR Araport; AT5G54580; -.
DR TAIR; locus:2172144; AT5G54580.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_012062_28_4_1; -.
DR InParanoid; Q9FIU6; -.
DR OMA; PLADPCN; -.
DR OrthoDB; 1524134at2759; -.
DR PhylomeDB; Q9FIU6; -.
DR PRO; PR:Q9FIU6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIU6; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0080156; P:mitochondrial mRNA modification; IMP:TAIR.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; mRNA processing; Phosphoprotein; Reference proteome;
KW RNA-binding; Transit peptide.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 29..156
FT /note="Organelle RRM domain-containing protein 2,
FT mitochondrial"
FT /id="PRO_0000439869"
FT DOMAIN 56..134
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 137..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8RWN5"
SQ SEQUENCE 156 AA; 17090 MW; 3AD21BCF753F9A73 CRC64;
MAMAMRLPAI SRAVTEVASA PVGLRRLFCS NASRFSFLSP QAESQTPARP QAEPSTNLFV
SGLSKRTTSE GLRTAFAQFG EVADAKVVTD RVSGYSKGFG FVRYATLEDS AKGIAGMDGK
FLDGWVIFAE YARPREQSQS YQPQNNMSRP PYYGNR
