ORS1_ARATH
ID ORS1_ARATH Reviewed; 88 AA.
AC Q8RWS1; Q9ZVB4;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Protein ORGAN SIZE RELATED 1;
GN Name=ORS1; OrderedLocusNames=At2g41230; ORFNames=F13H10.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP OSR DOMAIN, AND INDUCTION BY HORMONES.
RC STRAIN=cv. Columbia;
RX PubMed=21457262; DOI=10.1111/j.1469-8137.2011.03710.x;
RA Feng G., Qin Z., Yan J., Zhang X., Hu Y.;
RT "Arabidopsis ORGAN SIZE RELATED1 regulates organ growth and final organ
RT size in orchestration with ARGOS and ARL.";
RL New Phytol. 191:635-646(2011).
CC -!- FUNCTION: Together with ARGOS and ARL, regulates organ growth and final
CC organ size. Promotes both cell expansion and proliferation-dependent
CC organ growth, in an ANT-dependent manner.
CC {ECO:0000269|PubMed:21457262}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Endoplasmic reticulum
CC {ECO:0000269|PubMed:21457262}. Nucleus {ECO:0000250}. Cytoplasm
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers, and, to a lower
CC extent, in leaves and cotyledons. {ECO:0000269|PubMed:21457262}.
CC -!- DEVELOPMENTAL STAGE: Detected in leaf primordia. In leaves, present in
CC the blade and the petiole, especially at the dispersed meristematic
CC regions and the leaf margin. Accumulates in floral organs.
CC -!- INDUCTION: Induced by ethylene but repressed by abscisic acid (ABA) and
CC epi-brassinolide (epi-BL) treatments. {ECO:0000269|PubMed:21457262}.
CC -!- DOMAIN: The OSR domain is sufficient to promote organ growth.
CC -!- DISRUPTION PHENOTYPE: When associated with ARGOS disruption, reduction
CC in organ size. {ECO:0000269|PubMed:21457262}.
CC -!- SIMILARITY: Belongs to the plant organ size related (OSR) protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC78548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005662; AAC78548.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09947.1; -; Genomic_DNA.
DR EMBL; AY091149; AAM14097.1; -; mRNA.
DR EMBL; BT020283; AAV84504.1; -; mRNA.
DR EMBL; BT024631; ABD57456.1; -; mRNA.
DR PIR; D84839; D84839.
DR RefSeq; NP_850348.1; NM_180017.3.
DR AlphaFoldDB; Q8RWS1; -.
DR BioGRID; 4059; 1.
DR STRING; 3702.AT2G41230.1; -.
DR PaxDb; Q8RWS1; -.
DR PRIDE; Q8RWS1; -.
DR EnsemblPlants; AT2G41230.1; AT2G41230.1; AT2G41230.
DR GeneID; 818722; -.
DR Gramene; AT2G41230.1; AT2G41230.1; AT2G41230.
DR KEGG; ath:AT2G41230; -.
DR Araport; AT2G41230; -.
DR TAIR; locus:2040302; AT2G41230.
DR HOGENOM; CLU_2472238_0_0_1; -.
DR InParanoid; Q8RWS1; -.
DR OMA; SARRLMC; -.
DR PRO; PR:Q8RWS1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8RWS1; baseline and differential.
DR Genevisible; Q8RWS1; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071215; P:cellular response to abscisic acid stimulus; IEP:UniProtKB.
DR GO; GO:0071367; P:cellular response to brassinosteroid stimulus; IEP:UniProtKB.
DR GO; GO:0071369; P:cellular response to ethylene stimulus; IEP:UniProtKB.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:InterPro.
DR GO; GO:0090696; P:post-embryonic plant organ development; IGI:TAIR.
DR GO; GO:0051302; P:regulation of cell division; IMP:TAIR.
DR GO; GO:0001558; P:regulation of cell growth; IMP:TAIR.
DR GO; GO:0010104; P:regulation of ethylene-activated signaling pathway; IMP:TAIR.
DR GO; GO:2000070; P:regulation of response to water deprivation; IMP:TAIR.
DR InterPro; IPR037468; ARGOS/ARL/OSR1.
DR PANTHER; PTHR36023; PTHR36023; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Endoplasmic reticulum; Membrane; Nucleus;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..88
FT /note="Protein ORGAN SIZE RELATED 1"
FT /id="PRO_0000423600"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 25..76
FT /note="Organ Size Related (OSR) domain"
SQ SEQUENCE 88 AA; 9628 MW; 84BF044302FD28BC CRC64;
MRVHDQRLRF DVTPKPMGLN GSSLITARSV ALLLFLSLLL LILPPFLPPL PPPPATLLLL
PLLLMILLIF LAFSPSNEPS LAVEPLDP
