ID   ORSD_EMENI              Reviewed;         501 AA.
AC   Q5AUW7; C8V4V3;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Orsellinic acid/F9775 biosynthesis cluster protein D {ECO:0000303|PubMed:19666480};
GN   Name=orsD {ECO:0000303|PubMed:19666480}; ORFNames=AN7913;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   IDENTIFICATION OF THE ORS CLUSTER, FUNCTION, AND INDUCTION.
RX   PubMed=19666480; DOI=10.1073/pnas.0901870106;
RA   Schroeckh V., Scherlach K., Nuetzmann H.W., Shelest E., Schmidt-Heck W.,
RA   Schuemann J., Martin K., Hertweck C., Brakhage A.A.;
RT   "Intimate bacterial-fungal interaction triggers biosynthesis of archetypal
RT   polyketides in Aspergillus nidulans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:14558-14563(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=20174687; DOI=10.1039/b904541d;
RA   Sanchez J.F., Chiang Y.M., Szewczyk E., Davidson A.D., Ahuja M.,
RA   Elizabeth Oakley C., Woo Bok J., Keller N., Oakley B.R., Wang C.C.;
RT   "Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of
RT   Aspergillus nidulans.";
RL   Mol. Biosyst. 6:587-593(2010).
RN   [5]
RP   INDUCTION.
RX   PubMed=23892751; DOI=10.1128/aem.01578-13;
RA   Nuetzmann H.W., Fischer J., Scherlach K., Hertweck C., Brakhage A.A.;
RT   "Distinct amino acids of histone H3 control secondary metabolism in
RT   Aspergillus nidulans.";
RL   Appl. Environ. Microbiol. 79:6102-6109(2013).
RN   [6]
RP   INDUCTION.
RX   PubMed=23841751; DOI=10.1111/mmi.12326;
RA   Bok J.W., Soukup A.A., Chadwick E., Chiang Y.M., Wang C.C., Keller N.P.;
RT   "VeA and MvlA repression of the cryptic orsellinic acid gene cluster in
RT   Aspergillus nidulans involves histone 3 acetylation.";
RL   Mol. Microbiol. 89:963-974(2013).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and
CC       F9775 B (PubMed:19666480, PubMed:20174687). The non-reducing polyketide
CC       synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3
CC       malonyl-CoA units (PubMed:19666480, PubMed:20174687). Further
CC       modifications by the decarboxylase orsB and the tyrosinase-like protein
CC       orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).
CC       The functions of orsD and orsE remain unclear since only orsB and orsC
CC       are required to convert orsellinic acid into F9775 A and F9775 B
CC       (PubMed:20174687). {ECO:0000269|PubMed:19666480,
CC       ECO:0000269|PubMed:20174687}.
CC   -!- INDUCTION: Expression is induced by an intimate physical interaction of
CC       the fungal mycelia with the bacterium Streptomyces hygroscopicus
CC       (PubMed:19666480). Expression is repressed by VeA and MvlA via histone
CC       3 acetylation by the SAGA/ADA complex (PubMed:23892751,
CC       PubMed:23841751). {ECO:0000269|PubMed:19666480,
CC       ECO:0000269|PubMed:23841751, ECO:0000269|PubMed:23892751}.
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DR   EMBL; BN001302; CBF73511.1; -; Genomic_DNA.
DR   EMBL; AACD01000135; EAA59567.1; -; Genomic_DNA.
DR   RefSeq; XP_681182.1; XM_676090.1.
DR   AlphaFoldDB; Q5AUW7; -.
DR   EnsemblFungi; CBF73511; CBF73511; ANIA_07913.
DR   EnsemblFungi; EAA59567; EAA59567; AN7913.2.
DR   GeneID; 2868914; -.
DR   KEGG; ani:AN7913.2; -.
DR   eggNOG; ENOG502SKNG; Eukaryota.
DR   HOGENOM; CLU_024934_8_0_1; -.
DR   InParanoid; Q5AUW7; -.
DR   OMA; HWRESHG; -.
DR   OrthoDB; 715792at2759; -.
DR   Proteomes; UP000000560; Chromosome II.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR022698; OrsD.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF12013; OrsD; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..501
FT                   /note="Orsellinic acid/F9775 biosynthesis cluster protein
FT                   D"
FT                   /id="PRO_0000438569"
FT   REGION          137..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..167
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  55729 MW;  8DABA2F8EE792253 CRC64;
     MPPVRFGPRK ILEYDGRYGV LICHECRYAI QKSALQSHLL RHKIYRADRQ QLVAMINELD
     LLEPDDVLLP PPESPPIDGL PVIAGYRCTA PGCANLCASL KRMKGHWRES HGIADASLAR
     PAKLQTFFRG TKIRYFEVTP TTEDEDDEEN ESENDEEEGD VDLEEQEDDN GGRQSTTVTT
     SPGPSAPSVN VDLETLSYFH HFMSATSLTL PCPQDMQSGA QYWKEKAVPQ ALQQRWLMCG
     LLALAACHLA AFPDNAAAGQ QHRKRAAEFS LEFRTGWREL ADTSGEGLRE VATEIECLLR
     CAHWALAESP CDQRIMPEPG VPEHLQSIIS TIQSTVPAAA PHEAETSAYA TRILRWNTSE
     AGNSVLAEIR NRLHDLPARM ADTFGRPENI QDVLVLLSAL AAMGECCDTS FASEEVGPAW
     WGMATWWTRV PLRFKELVAR HYPASLVVVA HWAALMVNRT ERCGCWLVKG LAMTILLRIA
     ERLPEDDDGN VQRLVALTIA A