ID   ORTT_ECOL6              Reviewed;          57 AA.
AC   P64454; P76109;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Orphan toxin OrtT {ECO:0000305};
GN   Name=ortT {ECO:0000305}; OrderedLocusNames=c1870;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Acts as an orphan toxin which is important for maintaining
CC       cell fitness during stress related to the stringent response. Increases
CC       the formation of persister cells. Has no known antitoxin.
CC       {ECO:0000250|UniProtKB:P64453}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P64453}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GhoT/OrtT toxin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN80332.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN80332.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000061178.1; NC_004431.1.
DR   AlphaFoldDB; P64454; -.
DR   STRING; 199310.c1870; -.
DR   EnsemblBacteria; AAN80332; AAN80332; c1870.
DR   GeneID; 66674703; -.
DR   KEGG; ecc:c1870; -.
DR   eggNOG; ENOG5032ZDC; Bacteria.
DR   HOGENOM; CLU_189012_0_0_6; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019689; Toxin_GhoT/OrtT.
DR   Pfam; PF10753; Toxin_GhoT_OrtT; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Stress response; Toxin;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..57
FT                   /note="Orphan toxin OrtT"
FT                   /id="PRO_0000168934"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6646 MW;  11D1EE35781F61B1 CRC64;
     MSLYQHMLVF YAVMAAIAFL ITWFLSHDKK RIRFLSAFLV GATWPMSFPV ALLFSLF