ORYC_ASPOR
ID ORYC_ASPOR Reviewed; 538 AA.
AC P9WEZ6; Q2TXE9;
DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT 12-AUG-2020, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=MFS-type transporter oryC {ECO:0000303|PubMed:30104550};
DE AltName: Full=Oryzines biosynthesis cluster protein C {ECO:0000303|PubMed:30104550};
GN Name=oryC {ECO:0000303|PubMed:30104550}; ORFNames=AO090010000172;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION.
RX PubMed=30104550; DOI=10.3390/jof4030096;
RA Wasil Z., Kuhnert E., Simpson T.J., Cox R.J.;
RT "Oryzines A & B, maleidride congeners from Aspergillus oryzae and their
RT putative biosynthesis.";
RL J. Fungi 4:0-0(2018).
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of oryzines, natural products with an unusual
CC maleidride backbone. {ECO:0000269|PubMed:30104550}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE66074.1; Type=Erroneous gene model prediction; Note=The predicted gene AO090010000172 has been split into 2 genes: oryC and oryD.; Evidence={ECO:0000305|PubMed:30104550};
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DR EMBL; AP007175; BAE66074.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001827207.2; XM_001827155.2.
DR AlphaFoldDB; P9WEZ6; -.
DR SMR; P9WEZ6; -.
DR Proteomes; UP000006564; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..538
FT /note="MFS-type transporter oryC"
FT /id="PRO_0000450485"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 538 AA; 60397 MW; E4D75B91D7CCB51E CRC64;
MTVLTREKKP YFGLTGGWLT FWVTVACATD MSLFGYDQGV FSGVVITRDF LEVHDLVGPE
KTKTLSTVTA IYDVGCFFGA IVAFTIGEQL GRKKAILLGT TIMAIGAVLQ AASFSLAQMF
VGRIILGIGN GINTATAPIW QTETSQLKWR GKLVIFEMMM NIFGFCLVNW INYGLSFVGG
SIAWRFPLAF QFFFLIILWS TTPWLPESPR WLIAHGRQEE ATVVLSCLEA KPIDDPFVIA
QRNEIEFSVR YERENSMRWR DLCQKKGNDS KTLRRLLLGA GSQFMQQFGG INIMSYYLPT
VLMDSVGLSD TMARLLAACN ALSYLVFSGL AVLLVERIGR RGLMLLSTFG QFLCFLIITI
LLRFSRISDN GEKFASASVA FFFLYYGAFG IGMLGVPWLY PTEINSLPMR TKGAAVATAT
DWITNFVVVE ITPIGIKNID WKFWIVWTVT NAAFLPILYF LYPETANRSL EDMDEYYRSN
PALVVTKDPD AICRRRPQKY LQREEEEIER AAAAVDKRAL SVGAVEHAEW TNAMGNKS
