ID   ORYF_ASPOR              Reviewed;         480 AA.
AC   Q2TXF2;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=MFS-type transporter oryF {ECO:0000303|PubMed:30104550};
DE   AltName: Full=Oryzines biosynthesis cluster protein F {ECO:0000303|PubMed:30104550};
GN   Name=oryF {ECO:0000303|PubMed:30104550}; ORFNames=AO090010000169;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=30104550; DOI=10.3390/jof4030096;
RA   Wasil Z., Kuhnert E., Simpson T.J., Cox R.J.;
RT   "Oryzines A & B, maleidride congeners from Aspergillus oryzae and their
RT   putative biosynthesis.";
RL   J. Fungi 4:0-0(2018).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of oryzines, natural products with an unusual
CC       maleidride backbone. {ECO:0000269|PubMed:30104550}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP007175; BAE66071.1; -; Genomic_DNA.
DR   RefSeq; XP_001827204.1; XM_001827152.1.
DR   AlphaFoldDB; Q2TXF2; -.
DR   EnsemblFungi; BAE66071; BAE66071; AO090010000169.
DR   GeneID; 5999338; -.
DR   KEGG; aor:AO090010000169; -.
DR   VEuPathDB; FungiDB:AO090010000169; -.
DR   HOGENOM; CLU_008455_1_3_1; -.
DR   OMA; YQCIQAY; -.
DR   Proteomes; UP000006564; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..480
FT                   /note="MFS-type transporter oryF"
FT                   /id="PRO_0000450486"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  52844 MW;  6555E6FEFC00863B CRC64;
     MAEEVNERTR LLSQSDDPSP SLEELEEWEE PRNWKVSYRW LCIAVISVYG LISPVIAAII
     VPAMPQIATD LNVTDPGMLQ AFVSVYVLGW SFAPLVVGPL SEVYGRISLL NTGHGLFLVF
     NALCAFARSD YELLILRFIT GAVGSAPLSI GAGIIGDLWA PEERGLSISL YTLGPLLGPA
     IAPITGAYIV SHTSWRAIFA WCSLYILITW VVGLCTLRET FRPVLIQRKQ AAAVRKGQLP
     GSVQHHHKSL ADVFRQDLRR PFTFLGTQPI IQVLSLFMGY LFGLNHLSIT TFESVWTDIY
     NQTPSRAALN YISIAGGFIL GSQITGSLND RIYIYYTSKD PAKGTPELRT ILMLPAALLV
     PTGLLIYGWS AQTHSHWIMP NIGIGIYALG LIMSYQCIQA YVLDCYAVYA ASAMGALTIL
     RSLLGFVLPI LAPLIYRTLG YGWGSSLLAL WALVMGGLVP ILLWRYGAVL RKRSGILEEM