ID   ASB3_BOVIN              Reviewed;         525 AA.
AC   Q08DV6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 3;
DE            Short=ASB-3;
GN   Name=ASB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. Recognizes TNFRSF1B (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with ELOB and TNFRSF1B. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; BC123548; AAI23549.1; -; mRNA.
DR   RefSeq; NP_001070395.1; NM_001076927.1.
DR   AlphaFoldDB; Q08DV6; -.
DR   SMR; Q08DV6; -.
DR   STRING; 9913.ENSBTAP00000025921; -.
DR   PaxDb; Q08DV6; -.
DR   GeneID; 540802; -.
DR   KEGG; bta:540802; -.
DR   CTD; 51130; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; Q08DV6; -.
DR   OrthoDB; 1392423at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03722; SOCS_ASB3; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037329; ASB3_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 3.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 10.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..525
FT                   /note="Ankyrin repeat and SOCS box protein 3"
FT                   /id="PRO_0000283059"
FT   REPEAT          9..38
FT                   /note="ANK 1"
FT   REPEAT          42..71
FT                   /note="ANK 2"
FT   REPEAT          78..107
FT                   /note="ANK 3"
FT   REPEAT          111..140
FT                   /note="ANK 4"
FT   REPEAT          145..174
FT                   /note="ANK 5"
FT   REPEAT          178..207
FT                   /note="ANK 6"
FT   REPEAT          211..240
FT                   /note="ANK 7"
FT   REPEAT          246..275
FT                   /note="ANK 8"
FT   REPEAT          279..308
FT                   /note="ANK 9"
FT   REPEAT          315..346
FT                   /note="ANK 10"
FT   REPEAT          348..373
FT                   /note="ANK 11"
FT   DOMAIN          441..505
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   525 AA;  58633 MW;  720E0D60B9CA8897 CRC64;
     MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSIDVAD NRGWMPIHEA SYHNSVECLR
     MLIRADSSEN YIKTKTFEGF CALHLAASQG HWKIIQILLE AGADPNATTL EETTPLFLAV
     ENGQIDVLRL LLRYGANVNG SHSMCGWNAL HQASFQGNAE IIKLLLKKGA NKECQDDFGI
     TPLFVAAQYG KLESLSILIS SGADVNCQAL DKATPLFIAA QEGHTECVEL LLSSGADPDL
     YCNEDNWQLP IHAAAQMGHT KILDLLIPLT NRVCDTGPNK VSPVYSAVLG GHEECLEMLL
     QSGYSPDAQM CLVFGFSSPL CMAFQKDCDF FGIVNILLKY GAQLNELHLA YCLKYERFSV
     FRYFLKKCCP STPWDHISEF INHAIKAQTK YKEWLPSLLL AGFDPLNLLC SSWIDSVSDD
     ILIFTLEFTN WRRLPPAVEK MLSARASNSS WALQQHIASV PSLTHLCRLE IWSHLKLEHL
     QSDGFIRQLP LPRSLHDYLL YAEVLRMNEV PELAVFQDGE ISETT