ID   ORYN_ASPOR              Reviewed;         505 AA.
AC   Q2TXG1;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=MFS-type transporter oryN {ECO:0000303|PubMed:30104550};
DE   AltName: Full=Oryzines biosynthesis cluster protein N {ECO:0000303|PubMed:30104550};
GN   Name=oryN {ECO:0000303|PubMed:30104550}; ORFNames=AO090010000160;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=30104550; DOI=10.3390/jof4030096;
RA   Wasil Z., Kuhnert E., Simpson T.J., Cox R.J.;
RT   "Oryzines A & B, maleidride congeners from Aspergillus oryzae and their
RT   putative biosynthesis.";
RL   J. Fungi 4:0-0(2018).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of oryzines, natural products with an unusual
CC       maleidride backbone. {ECO:0000269|PubMed:30104550}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007175; BAE66062.1; -; Genomic_DNA.
DR   RefSeq; XP_001827195.1; XM_001827143.2.
DR   AlphaFoldDB; Q2TXG1; -.
DR   SMR; Q2TXG1; -.
DR   EnsemblFungi; BAE66062; BAE66062; AO090010000160.
DR   GeneID; 5999329; -.
DR   KEGG; aor:AO090010000160; -.
DR   VEuPathDB; FungiDB:AO090010000160; -.
DR   HOGENOM; CLU_008455_11_4_1; -.
DR   OMA; NFITASH; -.
DR   Proteomes; UP000006564; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..505
FT                   /note="MFS-type transporter oryN"
FT                   /id="PRO_0000450488"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  54702 MW;  A5102C084A17E02B CRC64;
     MAVAELPNIV STDSSPSPHP GSRLSSEPTD IESQKAPSNA EPKTDPNLVT WDGPDDPANP
     QNWSFAYRAF VTAIWVYGNL CTCIASSIFS SGSGQIAQRF HVGSTVVTLG ISLFLLGYTV
     GPPVWGPLSE RFGRKWPMVI GMALFTIFCI PVAVAKNLQT VLIGRFLTGV FGAAPLSLVG
     GSLVDMWNPA QRGVAMACCI GTIFGSPVLA PLMGNFIVES YLGWRFTQWL SCIMGGSCTV
     LVVFGLPETF AGSILRKKAA AIRKAGNPDV HTVYDGKQKG IKDIFVIFLL RPFALLVTEP
     ILLLVTIYQA FIYGILYLVF VSYPIAFREV RGWSLGISAL PYIGMMVGIL IGCAIVVIQT
     RRNYDGNKAV VPEQRLPLMI AGGCLLPVGL FIFAWTSNPN IHWAGMVIGS APVGTGMYMV
     FVQCLNYLVD VYPTIANSAI GANTFVRSFF GAGFPLFGPF MYHNLGVAWA SSTLGFISIA
     MIPIPVLFYR YGARIRSWSK NSKHT