ID   ORYO_ASPOR              Reviewed;         814 AA.
AC   Q2TXG2;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Transcription factor oryO {ECO:0000303|PubMed:30104550};
DE   AltName: Full=Oryzines biosynthesis cluster protein O {ECO:0000303|PubMed:30104550};
GN   Name=oryO {ECO:0000303|PubMed:30104550}; ORFNames=AO090010000159;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=30104550; DOI=10.3390/jof4030096;
RA   Wasil Z., Kuhnert E., Simpson T.J., Cox R.J.;
RT   "Oryzines A & B, maleidride congeners from Aspergillus oryzae and their
RT   putative biosynthesis.";
RL   J. Fungi 4:0-0(2018).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of oryzines, natural
CC       products with an unusual maleidride backbone.
CC       {ECO:0000269|PubMed:30104550}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; AP007175; BAE66061.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2TXG2; -.
DR   EnsemblFungi; BAE66061; BAE66061; AO090010000159.
DR   HOGENOM; CLU_366887_0_0_1; -.
DR   OMA; PACNQCR; -.
DR   Proteomes; UP000006564; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..814
FT                   /note="Transcription factor oryO"
FT                   /id="PRO_0000450489"
FT   DNA_BIND        58..85
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          699..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        704..723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  91054 MW;  D1783F9CEDC39ACE CRC64;
     MTARTPNRAT GAPENANPTV RDQTQQDQGE RSESPAIPSL TNKKRPRSQP DNTSSPACNQ
     CRTRKIRCDR QQPKCSNCRR ADVECDFATT PKRVDRTKQL LNDFSGVVAR LDRVDNSLAK
     LSEQLQQQQP CRCSHSPVPS QVDNPWGASE PAAIYTTYTP KSSTSCRSPH LMEVDGSEDC
     DPEIPNGDLV DFDQGGQRLL DYPAALSLFK NLQRQITRWL TKDVPQGSEL WQVIAQQPGF
     KASLEYQLEQ FPFGGLCHEP VIVSDHRPIS TPPRYLLELS LDGFLRHINI HTPIFDDSSL
     GKAIDTHYQS LSAGTGDAWA LTFTNIIILT VALDARVARA TASHLVSMND DMLPSFLKNC
     DRALADLNRF TAPCLINVQV LLTLVRMVIN FPEAYIRALV AREFYGSVVF EKVCQAVCQV
     ARSTGLHRAH GARSMRWEKM PERERLFWVV YTMDKQRAFL TGQPCDLYLF DSDIQLRSCG
     ERAPFPLRLN AAYVHMMTIW EQIFINLYSS RAVLAGAADR SRQVQQLWGS LNEWNIKYHA
     LLSSPILEKM ADLAPMQLEL KYCFMVSQVL VHRCDRNARS QQRYRDPARS ALKLIAQVAG
     DHRSITLARC AVLARMFRNY PLVAVHDLFS FCLTDGEPDS TEDGQLIHET RRHLELLHYA
     DFPQAYFARL EVGLKWCTDM LDTIKDCLSR SAVAGDWGPM DGSSTGLSDR TPPSESELSS
     IPPDAWASLN LPMSRDEMLC GLSPSVPSEG LLDPQFSAFG LTTSSTGDST VPAFAQGGDN
     PAVTMHPSMW VPAEVPCNSS EPLFDPEFTR SIMS