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OS24_PLABA
ID   OS24_PLABA              Reviewed;         213 AA.
AC   Q04620;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=24 kDa ookinete surface protein;
DE   AltName: Full=Pbs21;
DE   Flags: Precursor;
OS   Plasmodium berghei (strain Anka).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8341324; DOI=10.1016/0166-6851(93)90224-l;
RA   Paton M.J., Barker G.C., Matsuoka H., Ramesar J., Janse C.J., Waters A.P.,
RA   Sinden R.E.;
RT   "Structure and expression of a post-transcriptionally regulated malaria
RT   gene encoding a surface protein from the sexual stages of Plasmodium
RT   berghei.";
RL   Mol. Biochem. Parasitol. 59:263-276(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7694225;
RA   Sinden R.E., Barker G.C., Paton M.J., Fleck S.L., Butcher G.A., Waters A.,
RA   Janse C.J., Rodriguez M.H.;
RT   "Factors regulating natural transmission of Plasmodium berghei to the
RT   mosquito vector, and the cloning of a transmission-blocking immunogen.";
RL   Parassitologia 35:107-112(1993).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during gametogenesis. It first appears
CC       on the macrogamete and zygote 1-2 hours after fertilization, reaching a
CC       maximum 10 hours later on the young ookinete and persisting during
CC       early oocyst development.
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DR   EMBL; X68402; CAA48468.1; -; mRNA.
DR   EMBL; S67121; AAB28814.1; -; mRNA.
DR   PIR; S25647; S25647.
DR   RefSeq; XP_675906.1; XM_670814.1.
DR   AlphaFoldDB; Q04620; -.
DR   SMR; Q04620; -.
DR   STRING; 5821.PBANKA_051490; -.
DR   ABCD; Q04620; 1 sequenced antibody.
DR   VEuPathDB; PlasmoDB:PBANKA_0514900; -.
DR   eggNOG; ENOG502QXSU; Eukaryota.
DR   HOGENOM; CLU_1296629_0_0_1; -.
DR   OMA; IRYNNAK; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009986; C:cell surface; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR010423; Pvs25/Psv28_EGF.
DR   Pfam; PF06247; Plasmod_Pvs28; 3.
DR   SMART; SM00181; EGF; 3.
DR   PROSITE; PS01186; EGF_2; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Malaria; Membrane; Repeat; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..190
FT                   /note="24 kDa ookinete surface protein"
FT                   /id="PRO_0000024565"
FT   PROPEP          191..213
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000024566"
FT   DOMAIN          30..59
FT                   /note="EGF-like 1; truncated"
FT   DOMAIN          60..108
FT                   /note="EGF-like 2"
FT   DOMAIN          108..148
FT                   /note="EGF-like 3"
FT   DOMAIN          151..175
FT                   /note="EGF-like 4; truncated"
FT   LIPID           190
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        64..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        74..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        96..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        112..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        117..134
FT                   /evidence="ECO:0000250"
FT   DISULFID        136..147
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  23520 MW;  F035CE6B6DD8EE81 CRC64;
     MNFKYSFIFL FFIQLAIRYN NAKITVDTIC KGGKLIQMSN HYECKCPSGY ALKTENTCEP
     IVKCDKLENI NKVCGEYSIC INQGNFGLEK AFVCMCTNGY MLSQNICKPT RCYNYECNAG
     KCILDSINPN NPVCSCDIGK ILQNGKCTGT GETKCLLKCK AAEECKLTGK HYECVSKPQA
     PGTGSETPSN SSFMNGMSII SIIALLVIYV IVM
 
 
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