OS24_PLABA
ID OS24_PLABA Reviewed; 213 AA.
AC Q04620;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=24 kDa ookinete surface protein;
DE AltName: Full=Pbs21;
DE Flags: Precursor;
OS Plasmodium berghei (strain Anka).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8341324; DOI=10.1016/0166-6851(93)90224-l;
RA Paton M.J., Barker G.C., Matsuoka H., Ramesar J., Janse C.J., Waters A.P.,
RA Sinden R.E.;
RT "Structure and expression of a post-transcriptionally regulated malaria
RT gene encoding a surface protein from the sexual stages of Plasmodium
RT berghei.";
RL Mol. Biochem. Parasitol. 59:263-276(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7694225;
RA Sinden R.E., Barker G.C., Paton M.J., Fleck S.L., Butcher G.A., Waters A.,
RA Janse C.J., Rodriguez M.H.;
RT "Factors regulating natural transmission of Plasmodium berghei to the
RT mosquito vector, and the cloning of a transmission-blocking immunogen.";
RL Parassitologia 35:107-112(1993).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during gametogenesis. It first appears
CC on the macrogamete and zygote 1-2 hours after fertilization, reaching a
CC maximum 10 hours later on the young ookinete and persisting during
CC early oocyst development.
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DR EMBL; X68402; CAA48468.1; -; mRNA.
DR EMBL; S67121; AAB28814.1; -; mRNA.
DR PIR; S25647; S25647.
DR RefSeq; XP_675906.1; XM_670814.1.
DR AlphaFoldDB; Q04620; -.
DR SMR; Q04620; -.
DR STRING; 5821.PBANKA_051490; -.
DR ABCD; Q04620; 1 sequenced antibody.
DR VEuPathDB; PlasmoDB:PBANKA_0514900; -.
DR eggNOG; ENOG502QXSU; Eukaryota.
DR HOGENOM; CLU_1296629_0_0_1; -.
DR OMA; IRYNNAK; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR010423; Pvs25/Psv28_EGF.
DR Pfam; PF06247; Plasmod_Pvs28; 3.
DR SMART; SM00181; EGF; 3.
DR PROSITE; PS01186; EGF_2; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein; GPI-anchor;
KW Lipoprotein; Malaria; Membrane; Repeat; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..190
FT /note="24 kDa ookinete surface protein"
FT /id="PRO_0000024565"
FT PROPEP 191..213
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000024566"
FT DOMAIN 30..59
FT /note="EGF-like 1; truncated"
FT DOMAIN 60..108
FT /note="EGF-like 2"
FT DOMAIN 108..148
FT /note="EGF-like 3"
FT DOMAIN 151..175
FT /note="EGF-like 4; truncated"
FT LIPID 190
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 64..80
FT /evidence="ECO:0000250"
FT DISULFID 74..94
FT /evidence="ECO:0000250"
FT DISULFID 96..107
FT /evidence="ECO:0000250"
FT DISULFID 112..122
FT /evidence="ECO:0000250"
FT DISULFID 117..134
FT /evidence="ECO:0000250"
FT DISULFID 136..147
FT /evidence="ECO:0000250"
SQ SEQUENCE 213 AA; 23520 MW; F035CE6B6DD8EE81 CRC64;
MNFKYSFIFL FFIQLAIRYN NAKITVDTIC KGGKLIQMSN HYECKCPSGY ALKTENTCEP
IVKCDKLENI NKVCGEYSIC INQGNFGLEK AFVCMCTNGY MLSQNICKPT RCYNYECNAG
KCILDSINPN NPVCSCDIGK ILQNGKCTGT GETKCLLKCK AAEECKLTGK HYECVSKPQA
PGTGSETPSN SSFMNGMSII SIIALLVIYV IVM
