OS25_PLAGA
ID OS25_PLAGA Reviewed; 215 AA.
AC P13401;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=25 kDa ookinete surface antigen;
DE AltName: Full=Pgs25;
DE Flags: Precursor;
OS Plasmodium gallinaceum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Haemamoeba).
OX NCBI_TaxID=5849;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2468086; DOI=10.1016/0166-6851(89)90090-x;
RA Kaslow D.C., Syin C., McCutchan T.F., Miller L.H.;
RT "Comparison of the primary structure of the 25 kDa ookinete surface
RT antigens of Plasmodium falciparum and Plasmodium gallinaceum reveal six
RT conserved regions.";
RL Mol. Biochem. Parasitol. 33:283-287(1989).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed on zygotes and ookinetes.
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DR EMBL; J04008; AAA29487.1; -; mRNA.
DR AlphaFoldDB; P13401; -.
DR SMR; P13401; -.
DR VEuPathDB; PlasmoDB:PGAL8A_00490300; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR010423; Pvs25/Psv28_EGF.
DR Pfam; PF06247; Plasmod_Pvs28; 2.
DR SMART; SM00181; EGF; 4.
DR PROSITE; PS01186; EGF_2; 3.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein; GPI-anchor;
KW Lipoprotein; Malaria; Membrane; Repeat; Signal.
FT SIGNAL 1..16
FT CHAIN 17..192
FT /note="25 kDa ookinete surface antigen"
FT /id="PRO_0000024569"
FT PROPEP 193..215
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000024570"
FT DOMAIN 29..58
FT /note="EGF-like 1; truncated"
FT DOMAIN 59..104
FT /note="EGF-like 2"
FT DOMAIN 104..148
FT /note="EGF-like 3"
FT DOMAIN 151..191
FT /note="EGF-like 4"
FT LIPID 192
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 63..78
FT /evidence="ECO:0000250"
FT DISULFID 72..90
FT /evidence="ECO:0000250"
FT DISULFID 92..103
FT /evidence="ECO:0000250"
FT DISULFID 108..118
FT /evidence="ECO:0000250"
FT DISULFID 113..131
FT /evidence="ECO:0000250"
FT DISULFID 133..147
FT /evidence="ECO:0000250"
FT DISULFID 155..166
FT /evidence="ECO:0000250"
FT DISULFID 159..175
FT /evidence="ECO:0000250"
FT DISULFID 177..190
FT /evidence="ECO:0000250"
SQ SEQUENCE 215 AA; 24556 MW; 10FAEB06676D4DC9 CRC64;
MNMSYLFFFF FIQLVLKYIN SKVTENTICK DGFLIQMSNH FECNCNPGFV LTSESTCENK
VECNANSLDK RCGDFSKCAY KDLQQKELTC KCIDGYDLEE SICVPNECKN FRCESGKCVL
DPKQEAKIPM CSCFIGIVPS KENNNTCTIE GQTECTLKCT KENETCKKTS GIYKCDCKDG
YTFDKEENAC ISFSLFNILN LSIIFIISLI YFYII
