OS25_PLARE
ID OS25_PLARE Reviewed; 217 AA.
AC P19455;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=25 kDa ookinete surface antigen;
DE AltName: Full=Prs25;
DE Flags: Precursor;
OS Plasmodium reichenowi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5854;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2290442; DOI=10.1016/0166-6851(90)90139-d;
RA Lal A.A., Goldman I.F., Campbell G.H.;
RT "Primary structure of the 25-kilodalton ookinete antigen from Plasmodium
RT reichenowi.";
RL Mol. Biochem. Parasitol. 43:143-145(1990).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed on zygotes and ookinetes.
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DR EMBL; M36915; AAA29455.1; -; Genomic_DNA.
DR PIR; A44966; A44966.
DR AlphaFoldDB; P19455; -.
DR SMR; P19455; -.
DR PRIDE; P19455; -.
DR VEuPathDB; PlasmoDB:PRCDC_1030300; -.
DR VEuPathDB; PlasmoDB:PRG01_1029500; -.
DR PhylomeDB; P19455; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR010423; Pvs25/Psv28_EGF.
DR Pfam; PF06247; Plasmod_Pvs28; 4.
DR SMART; SM00181; EGF; 3.
DR PROSITE; PS01186; EGF_2; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein; GPI-anchor;
KW Lipoprotein; Malaria; Membrane; Repeat; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000250"
FT CHAIN 17..196
FT /note="25 kDa ookinete surface antigen"
FT /id="PRO_0000024571"
FT PROPEP 197..217
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000024572"
FT DOMAIN 30..59
FT /note="EGF-like 1; truncated"
FT DOMAIN 61..106
FT /note="EGF-like 2"
FT DOMAIN 106..150
FT /note="EGF-like 3"
FT DOMAIN 153..193
FT /note="EGF-like 4"
FT LIPID 196
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..80
FT /evidence="ECO:0000250"
FT DISULFID 74..92
FT /evidence="ECO:0000250"
FT DISULFID 94..105
FT /evidence="ECO:0000250"
FT DISULFID 110..120
FT /evidence="ECO:0000250"
FT DISULFID 115..133
FT /evidence="ECO:0000250"
FT DISULFID 135..149
FT /evidence="ECO:0000250"
FT DISULFID 157..168
FT /evidence="ECO:0000250"
FT DISULFID 161..177
FT /evidence="ECO:0000250"
FT DISULFID 179..192
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24085 MW; 20AAD8E0D982A3FA CRC64;
MNKLYSLFLF LFIQLSIKYY NAKVTVDTVC KKGFLIQMSG HLECKCENDL VLVNEETCEE
KVLKCDETTV NKPCGDFSKC IKIDGSPISY ACKCNPGYDM VNNVCILNEC KNVTCGNGKC
ILDTSNPVKT GVCSCNIGKV PNADDKNKCS KDGETKCSLK CLKENETCKA VDGIYKCDCK
DGFIMDNESS TCTAFSVYNI LNLSLIFVLF SVCFFIM
