ID   OSB11_DICDI             Reviewed;         571 AA.
AC   Q54ID7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Oxysterol-binding protein 11;
DE   AltName: Full=OSBPk;
GN   Name=osbK; ORFNames=DDB_G0288817;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000125; EAL63030.1; -; Genomic_DNA.
DR   RefSeq; XP_636540.1; XM_631448.1.
DR   AlphaFoldDB; Q54ID7; -.
DR   SMR; Q54ID7; -.
DR   STRING; 44689.DDB0237799; -.
DR   PaxDb; Q54ID7; -.
DR   PRIDE; Q54ID7; -.
DR   EnsemblProtists; EAL63030; EAL63030; DDB_G0288817.
DR   GeneID; 8626825; -.
DR   KEGG; ddi:DDB_G0288817; -.
DR   dictyBase; DDB_G0288817; osbK.
DR   eggNOG; KOG1737; Eukaryota.
DR   HOGENOM; CLU_477718_0_0_1; -.
DR   InParanoid; Q54ID7; -.
DR   OMA; FRIICEQ; -.
DR   PhylomeDB; Q54ID7; -.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   PRO; PR:Q54ID7; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..571
FT                   /note="Oxysterol-binding protein 11"
FT                   /id="PRO_0000328472"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          387..420
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   571 AA;  65946 MW;  0AEF3B122D895455 CRC64;
     MSNFFKKLVK KDGTPKSSRK SKSESPVGKY DMNGNQVVPD TASSYSDDSN SLSDSYDKRG
     EPNIGEQIDT LDDYNFGNEI GDAESAPEDK KSLWKKVGGL VGKDPMSLVS LPVYFFEPLT
     VLECQLEPLR FVELIEKAST CSDSIDRLMY LTAFNIAVFS SYTRTAKPFN PLLGETFEYI
     DKQGRYKSFC EQVSHHPPIG IAQTTSEIFD LQQESWITTK FWGNSLDVFS HGQNHLYLNS
     TGEHFTWKVP SAICHNIIFG KMWIEHYGDL IVENHNTGEK AIINFQKSGW FEGTQRKVQG
     EILDSKGNAR VHINGKWDKY VKAKKHSEGP SRKSSGEITL WEATIEPPEN FNKWKHGKWI
     QGLNEMSKEY QAVLPSTDSR VRMDRIYLER EENKLANKEK NKIEEREREK RKTRESRKEI
     WKPNYFSKRE DSKYGYRWDF NGKYWDERDK RVDSVVDKFK NDPNFDSNKI PEYDDSKLNI
     SVKSVRKFSR DFTNSSTPTQ LKRSFSKLKL EEQPQSQSLP PMIKEELSSS TVDHEETFYS
     ESNEAKLESI KEDANSHTYI YSSPTIGHSG R