ID   ASB5_BOVIN              Reviewed;         329 AA.
AC   Q17QS6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 5;
DE            Short=ASB-5;
GN   Name=ASB5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. May play a role in the initiation of
CC       arteriogenesis (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; BC118205; AAI18206.1; -; mRNA.
DR   RefSeq; NP_001069212.1; NM_001075744.1.
DR   AlphaFoldDB; Q17QS6; -.
DR   SMR; Q17QS6; -.
DR   STRING; 9913.ENSBTAP00000018799; -.
DR   PaxDb; Q17QS6; -.
DR   Ensembl; ENSBTAT00000018799; ENSBTAP00000018799; ENSBTAG00000014143.
DR   GeneID; 516722; -.
DR   KEGG; bta:516722; -.
DR   CTD; 140458; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014143; -.
DR   VGNC; VGNC:26198; ASB5.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000159851; -.
DR   HOGENOM; CLU_000134_4_1_1; -.
DR   InParanoid; Q17QS6; -.
DR   OrthoDB; 1546307at2759; -.
DR   TreeFam; TF331945; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000014143; Expressed in gluteus medius and 85 other tissues.
DR   ExpressionAtlas; Q17QS6; baseline.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   CDD; cd03724; SOCS_ASB5; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037328; ASB5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..329
FT                   /note="Ankyrin repeat and SOCS box protein 5"
FT                   /id="PRO_0000283055"
FT   REPEAT          69..98
FT                   /note="ANK 1"
FT   REPEAT          102..131
FT                   /note="ANK 2"
FT   REPEAT          135..164
FT                   /note="ANK 3"
FT   REPEAT          167..196
FT                   /note="ANK 4"
FT   REPEAT          200..229
FT                   /note="ANK 5"
FT   REPEAT          232..261
FT                   /note="ANK 6"
FT   DOMAIN          278..329
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   329 AA;  36380 MW;  2EE2E5D02A9DCD33 CRC64;
     MSMVEENRPF AQQLSNVYFT ILSLFCFKLF VKISLAILSH FYIVKGNRKE AARIAAEFYG
     VTQGRGSWAD RSPLHEAASQ GRLLALRTLL SQGYNVNAVT IDHVTPLHEA CLGDHVACAR
     TLLQAGANVN AITIDGVTPL FNACSQGSTS CTELLLEYGA KPQLESCLPS PTHEAASKGH
     HECLEILISW GVDVDQDIPH LGTPLYVACM SQQFHCVRKL LYAGADVQKG KYWDTPLHAA
     AQQSCTEIVN LLLEFGADIN AKNTDLLRPV DVATSNSLVE RLLLQHEATP SSLCQLCRLC
     IRNYIGRPRL HLIPQLQLPT LLQNFLQYR