ID   OSB12_DICDI             Reviewed;         402 AA.
AC   Q54EF5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Oxysterol-binding protein 12;
DE   AltName: Full=OSBPl;
GN   Name=osbL; ORFNames=DDB_G0291562;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; AAFI02000177; EAL61765.1; -; Genomic_DNA.
DR   RefSeq; XP_635285.1; XM_630193.1.
DR   AlphaFoldDB; Q54EF5; -.
DR   SMR; Q54EF5; -.
DR   PaxDb; Q54EF5; -.
DR   EnsemblProtists; EAL61765; EAL61765; DDB_G0291562.
DR   GeneID; 8628229; -.
DR   KEGG; ddi:DDB_G0291562; -.
DR   dictyBase; DDB_G0291562; osbL.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_012334_1_0_1; -.
DR   InParanoid; Q54EF5; -.
DR   OMA; ECVYSTA; -.
DR   PhylomeDB; Q54EF5; -.
DR   Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q54EF5; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Oxysterol-binding protein 12"
FT                   /id="PRO_0000328476"
FT   REGION          333..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  46611 MW;  A3121E4A988143F7 CRC64;
     MSTETETHLG ESKRVILSSL IKQLSPNKEI KHMVLPCFLL QPRSTLESFT DMFTYIDELY
     KINEIDDEGE RFLQFVKFYL TGWHTRPKGI CKPFNPVIGE EFECFWSNNK NEDLPHIDEL
     IEDNNSDVGV FKAEQISHHP PLSAYVFYNK FQKILVNGNI CPSYVKFMGN SAESHLQGIL
     EFNFFKWNEC FECTLPTVGV KGIILGKLSP FTCGDIEIKS KNSKYSCKLE FLFKGLFGSS
     KNINGIKGTI LYDNKPIYKV RGNWDKQIFI KKINEIAGTH GGSSSGSHTN STERCLMDVS
     LLKNSKEKYT KPIEQQPPNS SYHLWELVTK NINNNNDKET AEEKAKIEEK QRKEESERRE
     KGILWEPKEF HFKENPNNEY KTTFYYNDIP KLFDNLQSKP IQ