ID   OSB2_DICDI              Reviewed;         391 AA.
AC   Q55CR3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Oxysterol-binding protein 2;
DE   AltName: Full=OSBPb;
GN   Name=osbB; ORFNames=DDB_G0269938;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000005; EAL72319.1; -; Genomic_DNA.
DR   RefSeq; XP_646418.1; XM_641326.1.
DR   AlphaFoldDB; Q55CR3; -.
DR   SMR; Q55CR3; -.
DR   STRING; 44689.DDB0237806; -.
DR   PaxDb; Q55CR3; -.
DR   EnsemblProtists; EAL72319; EAL72319; DDB_G0269938.
DR   GeneID; 8617375; -.
DR   KEGG; ddi:DDB_G0269938; -.
DR   dictyBase; DDB_G0269938; osbB.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_706815_0_0_1; -.
DR   InParanoid; Q55CR3; -.
DR   OMA; STHEYYS; -.
DR   PhylomeDB; Q55CR3; -.
DR   Reactome; R-DDI-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-DDI-192105; Synthesis of bile acids and bile salts.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q55CR3; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..391
FT                   /note="Oxysterol-binding protein 2"
FT                   /id="PRO_0000328468"
SQ   SEQUENCE   391 AA;  45269 MW;  298B5FAE83C24873 CRC64;
     MAKTKILNKN NKKEEIIDQE ENEVDVKTTC KELSPPTDLE IENLEKLENS GASRLHIVLS
     FIKKNGIGIG TDLTHFEFAS SFLLPHSTHE YYSDNMAREF DILLKSNIDN EIERLLGVFK
     YILSIKPIIE DSTRSPLRSV NGETKSSNFH VTIIDEQDKS EKIIKDNYYM VETLDQEKAF
     VGSCIYNKRE GVKVHFNTET KTIFNGTNIK LPIIGNIIIR FEKFNEEYTI TNPTLYGRYL
     RGFVEYCGET TITSKNSKYY IKKTNLAKPL IGGNVNMVEA KLLYGDDPNP LFKINGSWSN
     EMEIINCKTK ETKLLYKRPF NYFTKIIPDI LPTDSSIVWK DIIVPISKGE KINISKERSK
     ILEYQKKLNW KISQFHLNTD NNIWEPIIYK D